Role of unlabelled somatostatin analogues in the prevention of complications after elective pancreatic and peripancreatic surgery: A critical review

M. Falconi, R. Salvia, G. Mascetta, W. Mantovani, N. Sartori, G. Butturini, C. Bassi, P. Pederzoli

Research output: Contribution to journalArticle

Abstract

Although studies on the use of the somatostatin analogues in the elective pancreatic surgery are mostly prospective, double blind and randomised, the results are contradictory and not univocally interpretable. Through the examination of all randomised perspective works published on this subject, a critical interpretation is attempted which may give relevant suggestions for further studies. A new clinical, randomised, double blind and multicentric prospective trial should take into proper consideration even the changes which have occurred in the care of the patients. Over the years a significant decrease of postoperative hospital stay and a deeper awareness of the medical expenses have been observed. Moreover, since the drug has a potential advantage on specific pancreatic complications, only these must be considered among the end points of the study and the population studied will be limited exclusively to patients who underwent resection of the pancreatic head or of the periampullar region because of neoplastic disease. Finally, the selection of the centres that enrol the patients must be considered, since the expertise of each operator or of the team, affects, as an independent variable, both morbidity and mortality.

Original languageEnglish
JournalDigestive and Liver Disease
Volume36
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Feb 2004

Keywords

  • Complications
  • Pancreatic fistula
  • Pancreatic surgery
  • Somatostatin analogues

ASJC Scopus subject areas

  • Gastroenterology

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