Abstract
Background: The role of ventricular rate response (VRr) on the incidence of dementia in elderly subjects with cognitive impairment and atrial fibrillation (AF) is not known. Thus, we examined the ability of VRr to predict dementia in cognitively impaired elderly subjects with and without AF. Methods: A total of 358 cognitively impaired elderly subjects (MMSE 90) and moderate (>50/90 bpm) is predictive of dementia in the presence (HR = 7.70, 95% CI = 1.10-14.20, p = 0.03) but not in the absence (HR = 1.85; 95% CI = 0.78-4.47; p = 0.152) of AF. Conclusions: This study demonstrates that AF predicts dementia in elderly subjects with cognitive impairment. Moreover, VRr seems to play a key role in the incidence of dementia in cognitively impaired elderly subjects with AF.
| Original language | English |
|---|---|
| Pages (from-to) | 143-148 |
| Number of pages | 6 |
| Journal | Dementia and Geriatric Cognitive Disorders |
| Volume | 34 |
| Issue number | 3-4 |
| DOIs | |
| Publication status | Published - Dec 2012 |
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Keywords
- Atrial fibrillation
- Cardiac output
- Cognitive impairment
- Incidence dementia
- Rate ventricular response
ASJC Scopus subject areas
- Psychiatry and Mental health
- Geriatrics and Gerontology
- Cognitive Neuroscience
Cite this
Role of ventricular rate response on dementia in cognitively impaired elderly subjects with atrial fibrillation : A 10-year study. / Cacciatore, Francesco; Testa, Gianluca; Langellotto, Assunta; Galizia, Gianluigi; Della-Morte, David; Gargiulo, Gaetano; Bevilacqua, Agnese; Del Genio, Maria Teresa; Canonico, Vincenzo; Rengo, Franco; Abete, Pasquale.
In: Dementia and Geriatric Cognitive Disorders, Vol. 34, No. 3-4, 12.2012, p. 143-148.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Role of ventricular rate response on dementia in cognitively impaired elderly subjects with atrial fibrillation
T2 - A 10-year study
AU - Cacciatore, Francesco
AU - Testa, Gianluca
AU - Langellotto, Assunta
AU - Galizia, Gianluigi
AU - Della-Morte, David
AU - Gargiulo, Gaetano
AU - Bevilacqua, Agnese
AU - Del Genio, Maria Teresa
AU - Canonico, Vincenzo
AU - Rengo, Franco
AU - Abete, Pasquale
PY - 2012/12
Y1 - 2012/12
N2 - Background: The role of ventricular rate response (VRr) on the incidence of dementia in elderly subjects with cognitive impairment and atrial fibrillation (AF) is not known. Thus, we examined the ability of VRr to predict dementia in cognitively impaired elderly subjects with and without AF. Methods: A total of 358 cognitively impaired elderly subjects (MMSE 90) and moderate (>50/90 bpm) is predictive of dementia in the presence (HR = 7.70, 95% CI = 1.10-14.20, p = 0.03) but not in the absence (HR = 1.85; 95% CI = 0.78-4.47; p = 0.152) of AF. Conclusions: This study demonstrates that AF predicts dementia in elderly subjects with cognitive impairment. Moreover, VRr seems to play a key role in the incidence of dementia in cognitively impaired elderly subjects with AF.
AB - Background: The role of ventricular rate response (VRr) on the incidence of dementia in elderly subjects with cognitive impairment and atrial fibrillation (AF) is not known. Thus, we examined the ability of VRr to predict dementia in cognitively impaired elderly subjects with and without AF. Methods: A total of 358 cognitively impaired elderly subjects (MMSE 90) and moderate (>50/90 bpm) is predictive of dementia in the presence (HR = 7.70, 95% CI = 1.10-14.20, p = 0.03) but not in the absence (HR = 1.85; 95% CI = 0.78-4.47; p = 0.152) of AF. Conclusions: This study demonstrates that AF predicts dementia in elderly subjects with cognitive impairment. Moreover, VRr seems to play a key role in the incidence of dementia in cognitively impaired elderly subjects with AF.
KW - Atrial fibrillation
KW - Cardiac output
KW - Cognitive impairment
KW - Incidence dementia
KW - Rate ventricular response
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UR - http://www.scopus.com/inward/citedby.url?scp=84866143307&partnerID=8YFLogxK
U2 - 10.1159/000342195
DO - 10.1159/000342195
M3 - Article
C2 - 22986752
AN - SCOPUS:84866143307
VL - 34
SP - 143
EP - 148
JO - Dementia and Geriatric Cognitive Disorders
JF - Dementia and Geriatric Cognitive Disorders
SN - 1420-8008
IS - 3-4
ER -