Role of ventricular rate response on dementia in cognitively impaired elderly subjects with atrial fibrillation: A 10-year study

Francesco Cacciatore; Gianluca Testa; Assunta Langellotto; Gianluigi Galizia; David Della-Morte; Gaetano Gargiulo; Agnese Bevilacqua; Maria Teresa Del Genio; Vincenzo Canonico; Franco Rengo; Pasquale Abete

doi:10.1159/000342195

Role of ventricular rate response on dementia in cognitively impaired elderly subjects with atrial fibrillation: A 10-year study

Francesco Cacciatore, Gianluca Testa, Assunta Langellotto, Gianluigi Galizia, David Della-Morte, Gaetano Gargiulo, Agnese Bevilacqua, Maria Teresa Del Genio, Vincenzo Canonico, Franco Rengo, Pasquale Abete

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The role of ventricular rate response (VRr) on the incidence of dementia in elderly subjects with cognitive impairment and atrial fibrillation (AF) is not known. Thus, we examined the ability of VRr to predict dementia in cognitively impaired elderly subjects with and without AF. Methods: A total of 358 cognitively impaired elderly subjects (MMSE 90) and moderate (>50/90 bpm) is predictive of dementia in the presence (HR = 7.70, 95% CI = 1.10-14.20, p = 0.03) but not in the absence (HR = 1.85; 95% CI = 0.78-4.47; p = 0.152) of AF. Conclusions: This study demonstrates that AF predicts dementia in elderly subjects with cognitive impairment. Moreover, VRr seems to play a key role in the incidence of dementia in cognitively impaired elderly subjects with AF.

Original language	English
Pages (from-to)	143-148
Number of pages	6
Journal	Dementia and Geriatric Cognitive Disorders
Volume	34
Issue number	3-4
DOIs	https://doi.org/10.1159/000342195
Publication status	Published - Dec 2012

Keywords

Atrial fibrillation
Cardiac output
Cognitive impairment
Incidence dementia
Rate ventricular response

ASJC Scopus subject areas

Psychiatry and Mental health
Geriatrics and Gerontology
Cognitive Neuroscience

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Cacciatore, F., Testa, G., Langellotto, A., Galizia, G., Della-Morte, D., Gargiulo, G., Bevilacqua, A., Del Genio, M. T., Canonico, V., Rengo, F., & Abete, P. (2012). Role of ventricular rate response on dementia in cognitively impaired elderly subjects with atrial fibrillation: A 10-year study. Dementia and Geriatric Cognitive Disorders, 34(3-4), 143-148. https://doi.org/10.1159/000342195

Role of ventricular rate response on dementia in cognitively impaired elderly subjects with atrial fibrillation : A 10-year study. / Cacciatore, Francesco; Testa, Gianluca; Langellotto, Assunta; Galizia, Gianluigi; Della-Morte, David; Gargiulo, Gaetano; Bevilacqua, Agnese; Del Genio, Maria Teresa; Canonico, Vincenzo; Rengo, Franco; Abete, Pasquale.

In: Dementia and Geriatric Cognitive Disorders, Vol. 34, No. 3-4, 12.2012, p. 143-148.

Research output: Contribution to journal › Article › peer-review

Cacciatore, F, Testa, G, Langellotto, A, Galizia, G, Della-Morte, D, Gargiulo, G, Bevilacqua, A, Del Genio, MT, Canonico, V, Rengo, F & Abete, P 2012, 'Role of ventricular rate response on dementia in cognitively impaired elderly subjects with atrial fibrillation: A 10-year study', Dementia and Geriatric Cognitive Disorders, vol. 34, no. 3-4, pp. 143-148. https://doi.org/10.1159/000342195

Cacciatore, Francesco ; Testa, Gianluca ; Langellotto, Assunta ; Galizia, Gianluigi ; Della-Morte, David ; Gargiulo, Gaetano ; Bevilacqua, Agnese ; Del Genio, Maria Teresa ; Canonico, Vincenzo ; Rengo, Franco ; Abete, Pasquale. / Role of ventricular rate response on dementia in cognitively impaired elderly subjects with atrial fibrillation : A 10-year study. In: Dementia and Geriatric Cognitive Disorders. 2012 ; Vol. 34, No. 3-4. pp. 143-148.

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abstract = "Background: The role of ventricular rate response (VRr) on the incidence of dementia in elderly subjects with cognitive impairment and atrial fibrillation (AF) is not known. Thus, we examined the ability of VRr to predict dementia in cognitively impaired elderly subjects with and without AF. Methods: A total of 358 cognitively impaired elderly subjects (MMSE 90) and moderate (>50/90 bpm) is predictive of dementia in the presence (HR = 7.70, 95% CI = 1.10-14.20, p = 0.03) but not in the absence (HR = 1.85; 95% CI = 0.78-4.47; p = 0.152) of AF. Conclusions: This study demonstrates that AF predicts dementia in elderly subjects with cognitive impairment. Moreover, VRr seems to play a key role in the incidence of dementia in cognitively impaired elderly subjects with AF.",

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author = "Francesco Cacciatore and Gianluca Testa and Assunta Langellotto and Gianluigi Galizia and David Della-Morte and Gaetano Gargiulo and Agnese Bevilacqua and {Del Genio}, {Maria Teresa} and Vincenzo Canonico and Franco Rengo and Pasquale Abete",

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N2 - Background: The role of ventricular rate response (VRr) on the incidence of dementia in elderly subjects with cognitive impairment and atrial fibrillation (AF) is not known. Thus, we examined the ability of VRr to predict dementia in cognitively impaired elderly subjects with and without AF. Methods: A total of 358 cognitively impaired elderly subjects (MMSE 90) and moderate (>50/90 bpm) is predictive of dementia in the presence (HR = 7.70, 95% CI = 1.10-14.20, p = 0.03) but not in the absence (HR = 1.85; 95% CI = 0.78-4.47; p = 0.152) of AF. Conclusions: This study demonstrates that AF predicts dementia in elderly subjects with cognitive impairment. Moreover, VRr seems to play a key role in the incidence of dementia in cognitively impaired elderly subjects with AF.

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