Role of Vitamin D Receptor Activators in Cardio-Renal Syndromes

Mario Cozzolino, Elena Bruschetta, Andrea Stucchi, Claudio Ronco, Daniele Cusi

Research output: Contribution to journalArticlepeer-review


The involvement of vitamin D deficiency in cardiovascular morbidity and mortality is attracting great interest. In patients with chronic kidney disease this association is stronger because vitamin D levels decrease as a result of renal progressive impairment. In chronic kidney disease secondary hyperparathyroidism commonly occurs in response to persistent hypocalcemia and hyperphosphatemia; moreover, parathyroid gland volume increases, vascular calcification is accelerated, and structural and functional modifications of the left ventricle are observed. These alterations entail both cardiac and renal involvement, resulting in cardio-renal syndrome. Recent studies concluded that vitamin D administration seems to have cardioprotective and renoprotective effects and improve peripheral vascular disease, vascular calcification, cardiac outcome, and blood pressure control. In clinical practice, therefore, the use of this hormone may play an important role in cardio-renal syndrome prevention.

Original languageEnglish
Pages (from-to)63-69
Number of pages7
JournalSeminars in Nephrology
Issue number1
Publication statusPublished - Jan 2012


  • Chronic kidney disease
  • Dialysis
  • Mineral metabolism
  • Vitamin d

ASJC Scopus subject areas

  • Nephrology

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