Role of vitamin E-coated membrane in reducing advanced glycation end products in hemodialysis patients: A pilot study

I. Baragetti, S. Furiani, S. Vettoretti, S. Raselli, F. M. Maggi, F. Galli, A. L. Catapano, G. Buccianti

Research output: Contribution to journalArticle

Abstract

Introduction: Advanced glycation end products (AGEs) are markers of oxidative stress. Aims: To assess if a vitamin-E-coated dialyzer affects plasma AGE levels and endothelial function in hemodialysis patients. Methods: 16 patients were dialyzed with a synthetic modified cellulose membrane (SMC, n = 8) or a vitamin E-coated dialyzer (n = 8), respectively. At week 32 endothelial function was determined as brachial artery flow-mediated dilatation (FMD). Total AGEs, free pentosidine (FP), protein-bound pentosidine (BP) and autoantibodies against oxidized LDL (ox-LDL-autoantibodies) were assessed at baseline (T0) and at 16, 32, 40 and 42 weeks (T16, T32, T40 and T42). Results: At T16 and T32 FP and BP were lower in vitamin E than in SMC (T 16: 88.7 ± 8.96 vs. 124.2 ± 11.90 pmol/ml plasma; p = 0.04, and 22.9 ± 2.99 vs. 32.8 ± 2.98 pmol/mg proteins; p = 0.04. T32: 78.7 ± 8.54 vs. 123.7 ± 10.15 pmol/ml plasma; p = 0.007, and 19.9 ± 2.0 vs. 33.67 ± 2.41 pmol/mg proteins; p = 0.001). In vitamin E, AGEs were lower at T32, T40 and T42 (946.7 ± 80.91 vs. 1,351.2 ± 179.33 AU/ml, p = 0.05; 986.9 ± 59.63 vs. 1,509.9 ± 154.17 AU/ml, p = 0.013; 890.3 ± 73.70 vs. 1,453.9 ± 153.16 AU/ml, p = 0.009). At T32 AGEs, ox-LDL autoantibodies and FMD were inversely correlated (R = -0.70 p = 0.007 and R = -0.59, p = 0.04, respectively). Conclusions: Vit E-coated membrane reduces plasma AGEs levels and AGEs values are negatively correlated with FMD.

Original languageEnglish
Pages (from-to)369-376
Number of pages8
JournalBlood Purification
Volume24
Issue number4
DOIs
Publication statusPublished - Aug 2006

Keywords

  • Advanced glycation end products
  • Hemodialysis
  • Vitamin E-coated dialyzer

ASJC Scopus subject areas

  • Nephrology
  • Hematology

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    Baragetti, I., Furiani, S., Vettoretti, S., Raselli, S., Maggi, F. M., Galli, F., Catapano, A. L., & Buccianti, G. (2006). Role of vitamin E-coated membrane in reducing advanced glycation end products in hemodialysis patients: A pilot study. Blood Purification, 24(4), 369-376. https://doi.org/10.1159/000093678