Role of vitamin E-coated membrane in reducing advanced glycation end products in hemodialysis patients: A pilot study

I. Baragetti, S. Furiani, S. Vettoretti, S. Raselli, F. M. Maggi, F. Galli, A. L. Catapano, G. Buccianti

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Introduction: Advanced glycation end products (AGEs) are markers of oxidative stress. Aims: To assess if a vitamin-E-coated dialyzer affects plasma AGE levels and endothelial function in hemodialysis patients. Methods: 16 patients were dialyzed with a synthetic modified cellulose membrane (SMC, n = 8) or a vitamin E-coated dialyzer (n = 8), respectively. At week 32 endothelial function was determined as brachial artery flow-mediated dilatation (FMD). Total AGEs, free pentosidine (FP), protein-bound pentosidine (BP) and autoantibodies against oxidized LDL (ox-LDL-autoantibodies) were assessed at baseline (T0) and at 16, 32, 40 and 42 weeks (T16, T32, T40 and T42). Results: At T16 and T32 FP and BP were lower in vitamin E than in SMC (T 16: 88.7 ± 8.96 vs. 124.2 ± 11.90 pmol/ml plasma; p = 0.04, and 22.9 ± 2.99 vs. 32.8 ± 2.98 pmol/mg proteins; p = 0.04. T32: 78.7 ± 8.54 vs. 123.7 ± 10.15 pmol/ml plasma; p = 0.007, and 19.9 ± 2.0 vs. 33.67 ± 2.41 pmol/mg proteins; p = 0.001). In vitamin E, AGEs were lower at T32, T40 and T42 (946.7 ± 80.91 vs. 1,351.2 ± 179.33 AU/ml, p = 0.05; 986.9 ± 59.63 vs. 1,509.9 ± 154.17 AU/ml, p = 0.013; 890.3 ± 73.70 vs. 1,453.9 ± 153.16 AU/ml, p = 0.009). At T32 AGEs, ox-LDL autoantibodies and FMD were inversely correlated (R = -0.70 p = 0.007 and R = -0.59, p = 0.04, respectively). Conclusions: Vit E-coated membrane reduces plasma AGEs levels and AGEs values are negatively correlated with FMD.

Original languageEnglish
Pages (from-to)369-376
Number of pages8
JournalBlood Purification
Volume24
Issue number4
DOIs
Publication statusPublished - Aug 2006

Fingerprint

Advanced Glycosylation End Products
Vitamin E
Renal Dialysis
Autoantibodies
Dilatation
Membranes
Proteins
Brachial Artery
Cellulose
Oxidative Stress
Cell Membrane
pentosidine
oxidized low density lipoprotein

Keywords

  • Advanced glycation end products
  • Hemodialysis
  • Vitamin E-coated dialyzer

ASJC Scopus subject areas

  • Nephrology
  • Hematology

Cite this

Baragetti, I., Furiani, S., Vettoretti, S., Raselli, S., Maggi, F. M., Galli, F., ... Buccianti, G. (2006). Role of vitamin E-coated membrane in reducing advanced glycation end products in hemodialysis patients: A pilot study. Blood Purification, 24(4), 369-376. https://doi.org/10.1159/000093678

Role of vitamin E-coated membrane in reducing advanced glycation end products in hemodialysis patients : A pilot study. / Baragetti, I.; Furiani, S.; Vettoretti, S.; Raselli, S.; Maggi, F. M.; Galli, F.; Catapano, A. L.; Buccianti, G.

In: Blood Purification, Vol. 24, No. 4, 08.2006, p. 369-376.

Research output: Contribution to journalArticle

Baragetti, I, Furiani, S, Vettoretti, S, Raselli, S, Maggi, FM, Galli, F, Catapano, AL & Buccianti, G 2006, 'Role of vitamin E-coated membrane in reducing advanced glycation end products in hemodialysis patients: A pilot study', Blood Purification, vol. 24, no. 4, pp. 369-376. https://doi.org/10.1159/000093678
Baragetti, I. ; Furiani, S. ; Vettoretti, S. ; Raselli, S. ; Maggi, F. M. ; Galli, F. ; Catapano, A. L. ; Buccianti, G. / Role of vitamin E-coated membrane in reducing advanced glycation end products in hemodialysis patients : A pilot study. In: Blood Purification. 2006 ; Vol. 24, No. 4. pp. 369-376.
@article{302899afc9e3432f8e83b6b2b54602f0,
title = "Role of vitamin E-coated membrane in reducing advanced glycation end products in hemodialysis patients: A pilot study",
abstract = "Introduction: Advanced glycation end products (AGEs) are markers of oxidative stress. Aims: To assess if a vitamin-E-coated dialyzer affects plasma AGE levels and endothelial function in hemodialysis patients. Methods: 16 patients were dialyzed with a synthetic modified cellulose membrane (SMC, n = 8) or a vitamin E-coated dialyzer (n = 8), respectively. At week 32 endothelial function was determined as brachial artery flow-mediated dilatation (FMD). Total AGEs, free pentosidine (FP), protein-bound pentosidine (BP) and autoantibodies against oxidized LDL (ox-LDL-autoantibodies) were assessed at baseline (T0) and at 16, 32, 40 and 42 weeks (T16, T32, T40 and T42). Results: At T16 and T32 FP and BP were lower in vitamin E than in SMC (T 16: 88.7 ± 8.96 vs. 124.2 ± 11.90 pmol/ml plasma; p = 0.04, and 22.9 ± 2.99 vs. 32.8 ± 2.98 pmol/mg proteins; p = 0.04. T32: 78.7 ± 8.54 vs. 123.7 ± 10.15 pmol/ml plasma; p = 0.007, and 19.9 ± 2.0 vs. 33.67 ± 2.41 pmol/mg proteins; p = 0.001). In vitamin E, AGEs were lower at T32, T40 and T42 (946.7 ± 80.91 vs. 1,351.2 ± 179.33 AU/ml, p = 0.05; 986.9 ± 59.63 vs. 1,509.9 ± 154.17 AU/ml, p = 0.013; 890.3 ± 73.70 vs. 1,453.9 ± 153.16 AU/ml, p = 0.009). At T32 AGEs, ox-LDL autoantibodies and FMD were inversely correlated (R = -0.70 p = 0.007 and R = -0.59, p = 0.04, respectively). Conclusions: Vit E-coated membrane reduces plasma AGEs levels and AGEs values are negatively correlated with FMD.",
keywords = "Advanced glycation end products, Hemodialysis, Vitamin E-coated dialyzer",
author = "I. Baragetti and S. Furiani and S. Vettoretti and S. Raselli and Maggi, {F. M.} and F. Galli and Catapano, {A. L.} and G. Buccianti",
year = "2006",
month = "8",
doi = "10.1159/000093678",
language = "English",
volume = "24",
pages = "369--376",
journal = "Blood Purification",
issn = "0253-5068",
publisher = "S. Karger AG",
number = "4",

}

TY - JOUR

T1 - Role of vitamin E-coated membrane in reducing advanced glycation end products in hemodialysis patients

T2 - A pilot study

AU - Baragetti, I.

AU - Furiani, S.

AU - Vettoretti, S.

AU - Raselli, S.

AU - Maggi, F. M.

AU - Galli, F.

AU - Catapano, A. L.

AU - Buccianti, G.

PY - 2006/8

Y1 - 2006/8

N2 - Introduction: Advanced glycation end products (AGEs) are markers of oxidative stress. Aims: To assess if a vitamin-E-coated dialyzer affects plasma AGE levels and endothelial function in hemodialysis patients. Methods: 16 patients were dialyzed with a synthetic modified cellulose membrane (SMC, n = 8) or a vitamin E-coated dialyzer (n = 8), respectively. At week 32 endothelial function was determined as brachial artery flow-mediated dilatation (FMD). Total AGEs, free pentosidine (FP), protein-bound pentosidine (BP) and autoantibodies against oxidized LDL (ox-LDL-autoantibodies) were assessed at baseline (T0) and at 16, 32, 40 and 42 weeks (T16, T32, T40 and T42). Results: At T16 and T32 FP and BP were lower in vitamin E than in SMC (T 16: 88.7 ± 8.96 vs. 124.2 ± 11.90 pmol/ml plasma; p = 0.04, and 22.9 ± 2.99 vs. 32.8 ± 2.98 pmol/mg proteins; p = 0.04. T32: 78.7 ± 8.54 vs. 123.7 ± 10.15 pmol/ml plasma; p = 0.007, and 19.9 ± 2.0 vs. 33.67 ± 2.41 pmol/mg proteins; p = 0.001). In vitamin E, AGEs were lower at T32, T40 and T42 (946.7 ± 80.91 vs. 1,351.2 ± 179.33 AU/ml, p = 0.05; 986.9 ± 59.63 vs. 1,509.9 ± 154.17 AU/ml, p = 0.013; 890.3 ± 73.70 vs. 1,453.9 ± 153.16 AU/ml, p = 0.009). At T32 AGEs, ox-LDL autoantibodies and FMD were inversely correlated (R = -0.70 p = 0.007 and R = -0.59, p = 0.04, respectively). Conclusions: Vit E-coated membrane reduces plasma AGEs levels and AGEs values are negatively correlated with FMD.

AB - Introduction: Advanced glycation end products (AGEs) are markers of oxidative stress. Aims: To assess if a vitamin-E-coated dialyzer affects plasma AGE levels and endothelial function in hemodialysis patients. Methods: 16 patients were dialyzed with a synthetic modified cellulose membrane (SMC, n = 8) or a vitamin E-coated dialyzer (n = 8), respectively. At week 32 endothelial function was determined as brachial artery flow-mediated dilatation (FMD). Total AGEs, free pentosidine (FP), protein-bound pentosidine (BP) and autoantibodies against oxidized LDL (ox-LDL-autoantibodies) were assessed at baseline (T0) and at 16, 32, 40 and 42 weeks (T16, T32, T40 and T42). Results: At T16 and T32 FP and BP were lower in vitamin E than in SMC (T 16: 88.7 ± 8.96 vs. 124.2 ± 11.90 pmol/ml plasma; p = 0.04, and 22.9 ± 2.99 vs. 32.8 ± 2.98 pmol/mg proteins; p = 0.04. T32: 78.7 ± 8.54 vs. 123.7 ± 10.15 pmol/ml plasma; p = 0.007, and 19.9 ± 2.0 vs. 33.67 ± 2.41 pmol/mg proteins; p = 0.001). In vitamin E, AGEs were lower at T32, T40 and T42 (946.7 ± 80.91 vs. 1,351.2 ± 179.33 AU/ml, p = 0.05; 986.9 ± 59.63 vs. 1,509.9 ± 154.17 AU/ml, p = 0.013; 890.3 ± 73.70 vs. 1,453.9 ± 153.16 AU/ml, p = 0.009). At T32 AGEs, ox-LDL autoantibodies and FMD were inversely correlated (R = -0.70 p = 0.007 and R = -0.59, p = 0.04, respectively). Conclusions: Vit E-coated membrane reduces plasma AGEs levels and AGEs values are negatively correlated with FMD.

KW - Advanced glycation end products

KW - Hemodialysis

KW - Vitamin E-coated dialyzer

UR - http://www.scopus.com/inward/record.url?scp=33747045524&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33747045524&partnerID=8YFLogxK

U2 - 10.1159/000093678

DO - 10.1159/000093678

M3 - Article

C2 - 16755158

AN - SCOPUS:33747045524

VL - 24

SP - 369

EP - 376

JO - Blood Purification

JF - Blood Purification

SN - 0253-5068

IS - 4

ER -