Ropeginterferon alfa-2b versus phlebotomy in low-risk patients with polycythaemia vera (Low-PV study): a multicentre, randomised phase 2 trial

T. Barbui, A.M. Vannucchi, V. De Stefano, A. Masciulli, A. Carobbio, A. Ferrari, A. Ghirardi, E. Rossi, F. Ciceri, M. Bonifacio, A. Iurlo, F. Palandri, G. Benevolo, F. Pane, A. Ricco, G. Carli, M. Caramella, D. Rapezzi, C. Musolino, S. SiragusaE. Rumi, A. Patriarca, N. Cascavilla, B. Mora, E. Cacciola, C. Mannarelli, G.G. Loscocco, P. Guglielmelli, S. Betti, F. Lunghi, L. Scaffidi, C. Bucelli, N. Vianelli, M. Bellini, M.C. Finazzi, G. Tognoni, A. Rambaldi

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)e175-e184
JournalThe Lancet Haematology
Volume8
Issue number3
DOIs
Publication statusPublished - 2021

Keywords

  • acetylsalicylic acid
  • creatinine
  • ferritin
  • hydroxyurea
  • Janus kinase 2
  • ropeginterferon alpha2b
  • alpha interferon
  • JAK2 protein, human
  • macrogol
  • peginterferon alpha2b
  • recombinant protein
  • acute myeloid leukemia
  • adult
  • Article
  • asthenia
  • bleeding
  • bone marrow biopsy
  • claudication
  • comparative study
  • controlled study
  • coronary artery disease
  • decision making
  • drug efficacy
  • drug safety
  • erythromelalgia
  • female
  • flu like syndrome
  • hematocrit
  • human
  • hypercholesterolemia
  • hyperlipidemia
  • hyperplasia
  • hypertension
  • hypertransaminasemia
  • leukocyte count
  • leukocytosis
  • major clinical study
  • male
  • middle aged
  • multicenter study
  • myelofibrosis
  • neutropenia
  • paresthesia
  • phase 2 clinical trial
  • phlebotomy
  • polycythemia
  • pruritus
  • quality of life
  • questionnaire
  • randomized controlled trial
  • soft tissue injury
  • thrombocytosis
  • thrombosis
  • thyroid disease
  • treatment response
  • adolescent
  • adverse event
  • bone marrow
  • clinical trial
  • genetics
  • metabolism
  • pathology
  • polycythemia vera
  • single nucleotide polymorphism
  • treatment outcome
  • young adult
  • Adolescent
  • Adult
  • Bone Marrow
  • Female
  • Humans
  • Interferon alpha-2
  • Interferon-alpha
  • Janus Kinase 2
  • Male
  • Middle Aged
  • Neutropenia
  • Phlebotomy
  • Polycythemia Vera
  • Polyethylene Glycols
  • Polymorphism, Single Nucleotide
  • Quality of Life
  • Recombinant Proteins
  • Treatment Outcome
  • Young Adult

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