Ropivacaine vs bupivacaine in major surgery in infants

Giorgio Ivani, Elisabetta Lampugnani, Pasquale De Negri, Per Arne Lonnqvist, Lynn Broadman

Research output: Contribution to journalArticlepeer-review


Purpose: To assess and compare the onset time and duration of neuroblockade obtained after ropivacaine or bupivacaine in infants undergoing major abdominal surgery. We also evaluated the efficacy and safety of employing ropivacaine instead of bupivacaine to provide operative anesthesia and postoperative analgesia. Methods: In a prospective double blind study 28 infants, aged 1 - 12 months, undergoing elective major abdominal surgery, were randomly allocated to receive after induction of general anesthesia, either 0.7 ml·kg-1 bupivacaine 0.25% (group B) or ropivacaine 0.2% (group R) via lumbar epidural block. The onset time-total surgical time and duration of analgesia were recorded. Results: No differences were noted in demographic data, hemodynamic variables or duration of surgery. The onset time for sensory blockade was 13 min ± 2.1 (group B) and 11.7 ± 2.4 min (group R). The duration of analgesia was 491 ± 291 (group R) and 456 min ± 247 (group B). Eight patients in group B and six in group R needed codeine and acetaminophen rescue on at least one occasion during the 24 hr study period. No major side effects were noted in either groups. Conclusions: In infants undergoing major abdominal surgery under combined epidural/light general anesthesia, ropivacaine 0.2% produces sensory and motor blockade similar in onset, duration of action and efficacy to that obtained from an equal volume, 0.7 ml·kg-1, of bupivacaine 0.25%.

Original languageEnglish
Pages (from-to)467-469
Number of pages3
JournalCanadian Journal of Anesthesia
Issue number5 I
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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