Abstract
A role has recently been assigned to cell-mediated immunity in chronic liver diseases in addition to the well-known alterations of humoral immunity. We now report the results of the rosette inhibition test for the evaluation of T-lymphocyte 'sensitization' in patients with different chronic liver disorders. A cell-mediated immune reaction was found in 81 % of patients with chronic active hepatitis and in 71 % with primary biliary cirrhosis, whereas patients with chronic persistent hepatitis showed no reaction. The correlation with the incidence of hepatitis B antigen showed that T-lymphocyte sensitization was more frequent in the group of HB-positive patients. Finally, improvement of the test was observed in four out of nine patients given immunosuppressive treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 778-781 |
| Number of pages | 4 |
| Journal | Journal of Clinical Pathology |
| Volume | 29 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 1976 |
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ASJC Scopus subject areas
- Health Policy
- Pathology and Forensic Medicine
Cite this
Rosette inhibition test in chronic liver disease. / Salerno, F.; Fargion, S. R.; Cappellini, M. D.; Fiorelli, G.; Dioguardi, N.
In: Journal of Clinical Pathology, Vol. 29, No. 9, 1976, p. 778-781.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Rosette inhibition test in chronic liver disease
AU - Salerno, F.
AU - Fargion, S. R.
AU - Cappellini, M. D.
AU - Fiorelli, G.
AU - Dioguardi, N.
PY - 1976
Y1 - 1976
N2 - A role has recently been assigned to cell-mediated immunity in chronic liver diseases in addition to the well-known alterations of humoral immunity. We now report the results of the rosette inhibition test for the evaluation of T-lymphocyte 'sensitization' in patients with different chronic liver disorders. A cell-mediated immune reaction was found in 81 % of patients with chronic active hepatitis and in 71 % with primary biliary cirrhosis, whereas patients with chronic persistent hepatitis showed no reaction. The correlation with the incidence of hepatitis B antigen showed that T-lymphocyte sensitization was more frequent in the group of HB-positive patients. Finally, improvement of the test was observed in four out of nine patients given immunosuppressive treatment.
AB - A role has recently been assigned to cell-mediated immunity in chronic liver diseases in addition to the well-known alterations of humoral immunity. We now report the results of the rosette inhibition test for the evaluation of T-lymphocyte 'sensitization' in patients with different chronic liver disorders. A cell-mediated immune reaction was found in 81 % of patients with chronic active hepatitis and in 71 % with primary biliary cirrhosis, whereas patients with chronic persistent hepatitis showed no reaction. The correlation with the incidence of hepatitis B antigen showed that T-lymphocyte sensitization was more frequent in the group of HB-positive patients. Finally, improvement of the test was observed in four out of nine patients given immunosuppressive treatment.
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UR - http://www.scopus.com/inward/citedby.url?scp=0017092424&partnerID=8YFLogxK
U2 - 10.1136/jcp.29.9.778
DO - 10.1136/jcp.29.9.778
M3 - Article
VL - 29
SP - 778
EP - 781
JO - Journal of Clinical Pathology - Clinical Molecular Pathology
JF - Journal of Clinical Pathology - Clinical Molecular Pathology
SN - 0021-9746
IS - 9
ER -