Rotigotine and specific non-motor symptoms of Parkinson's disease: Post hoc analysis of RECOVER

K. Ray Chaudhuri, Pablo Martinez-Martin, Angelo Antonini, Richard G. Brown, Joseph H. Friedman, Marco Onofrj, Erwin Surmann, Liesbet Ghys, Claudia Trenkwalder

Research output: Contribution to journalArticlepeer-review


Background: Non-motor symptoms of Parkinson's disease (PD) represent major causes of morbidity. RECOVER, a randomized controlled trial of rotigotine transdermal system, was the first prospective controlled trial to use the Non-Motor Symptoms Scale (NMSS) as an exploratory outcome for assessment of treatment effects on non-motor symptoms in PD. Rotigotine improved NMSS total score compared with placebo, and the "Sleep/fatigue" and "Mood/apathy" domains. This post hoc analysis further characterizes the effects of rotigotine on sleep/fatigue and mood/apathy. Methods: Patients with PD and unsatisfactory early-morning motor impairment were randomized to transdermal patches of rotigotine (2-16 mg/24h) or placebo. Treatment was titrated to optimal dose over 1-8 weeks, maintained for 4 weeks. The NMSS was assessed at baseline and end of treatment. Post hoc analyses are presented for individual items of the "Sleep/fatigue" and "Mood/apathy" domains. The interpretation of p-values is considered exploratory in nature. Results: Of 287 patients randomized, NMSS data were available for 267 patients (178 rotigotine, 89 placebo). Within the "Sleep/fatigue" domain there was a significant difference, in favor of rotigotine, in change from baseline score in 1 of 5 items: "fatigue (tiredness) or lack of energy" (ANCOVA, p

Original languageEnglish
Pages (from-to)660-665
Number of pages6
JournalParkinsonism and Related Disorders
Issue number7
Publication statusPublished - Jul 2013


  • Fatigue
  • Mood
  • Non-motor symptoms
  • Parkinson's disease
  • Rotigotine

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Clinical Neurology
  • Neurology


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