rTMS for PTSD: Induced merciful oblivion or elimination of abnormal hypermnesia?

Simone Rossi, Stefano F. Cappa, Monica Ulivelli, Alberto De Capua, Sabina Bartalini, Paolo M. Rossini

Research output: Contribution to journalArticle

Abstract

Neuroimaging studies and experimental data suggest that symptoms of posttraumatic stress disorder (PTSD) are associated with dysfunctions of neural circuits linking prefrontal cortex and the limbic system that have a role in autobiographic episodic memory. High-frequency repetitive transcranial magnetic stimulation (rTMS) of the right dorsolateral prefrontal cortex (DLPFC) has been suggested to be beneficial to patients with PTSD, transiently alleviating re-experiencing as well as avoidance reactions and associated anxiety symptoms. In healthy humans, converging evidence suggests that rTMS of the right DLPFC interferes with episodic memory retrieval. Hence, we hypothesize that daily applications of rTMS in PTSD patients may reduce access to the set of autobiographical stored events, that, if re-experienced, may cause the overt PTSD symptoms.

Original languageEnglish
Pages (from-to)195-199
Number of pages5
JournalBehavioural Neurology
Volume17
Issue number3-4
Publication statusPublished - 2006

Keywords

  • Amnesia
  • Episodic memory
  • PTSD
  • rTMS
  • TMS

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

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  • Cite this

    Rossi, S., Cappa, S. F., Ulivelli, M., De Capua, A., Bartalini, S., & Rossini, P. M. (2006). rTMS for PTSD: Induced merciful oblivion or elimination of abnormal hypermnesia? Behavioural Neurology, 17(3-4), 195-199.