rTMS of supplementary motor area modulates therapy-induced dyskinesias in Parkinson disease

G. Koch; L. Brusa; C. Caltagirone; A. Peppe; M. Oliveri; P. Stanzione; D. Centonze

doi:10.1212/01.wnl.0000172861.36430.95

rTMS of supplementary motor area modulates therapy-induced dyskinesias in Parkinson disease

G. Koch, L. Brusa, C. Caltagirone, A. Peppe, M. Oliveri, P. Stanzione, D. Centonze

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

The neural mechanisms and circuitry involved in levodopa-induced dyskinesia are unclear. Using repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA) in a group of patients with advanced Parkinson disease, the authors investigated whether modulation of SMA excitability may result in a modification of a dyskinetic state induced by continuous apomorphine infusion. rTMS at 1 Hz was observed to markedly reduce drug-induced dyskinesias, whereas 5-Hz rTMS induced a slight but not significant increase.

Original language	English
Pages (from-to)	623-625
Number of pages	3
Journal	Neurology
Volume	65
Issue number	4
DOIs	https://doi.org/10.1212/01.wnl.0000172861.36430.95
Publication status	Published - Aug 23 2005

ASJC Scopus subject areas

Neuroscience(all)

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10.1212/01.wnl.0000172861.36430.95

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AU - Brusa, L.

AU - Caltagirone, C.

AU - Peppe, A.

AU - Oliveri, M.

AU - Stanzione, P.

AU - Centonze, D.

PY - 2005/8/23

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AB - The neural mechanisms and circuitry involved in levodopa-induced dyskinesia are unclear. Using repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA) in a group of patients with advanced Parkinson disease, the authors investigated whether modulation of SMA excitability may result in a modification of a dyskinetic state induced by continuous apomorphine infusion. rTMS at 1 Hz was observed to markedly reduce drug-induced dyskinesias, whereas 5-Hz rTMS induced a slight but not significant increase.

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rTMS of supplementary motor area modulates therapy-induced dyskinesias in Parkinson disease

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