rTMS of supplementary motor area modulates therapy-induced dyskinesias in Parkinson disease

G. Koch, L. Brusa, C. Caltagirone, A. Peppe, M. Oliveri, P. Stanzione, D. Centonze

Research output: Contribution to journal › Article › peer-review

Abstract

The neural mechanisms and circuitry involved in levodopa-induced dyskinesia are unclear. Using repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA) in a group of patients with advanced Parkinson disease, the authors investigated whether modulation of SMA excitability may result in a modification of a dyskinetic state induced by continuous apomorphine infusion. rTMS at 1 Hz was observed to markedly reduce drug-induced dyskinesias, whereas 5-Hz rTMS induced a slight but not significant increase.

Original languageEnglish
Pages (from-to)623-625
Number of pages3
JournalNeurology
Volume65
Issue number4
DOIs
Publication statusPublished - Aug 23 2005

ASJC Scopus subject areas

  • Neuroscience(all)

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