Rufinamide in refractory childhood epileptic encephalopathies other than Lennox-Gastaut syndrome

G. Coppola, S. Grosso, E. Franzoni, P. Veggiotti, N. Zamponi, P. Parisi, A. Spalice, F. Habetswallner, A. Fels, A. Verrotti, A. D'Aniello, S. Mangano, A. Balestri, P. Curatolo, A. Pascotto

Research output: Contribution to journalArticlepeer-review

Abstract

Background: To report on the first multicenter Italian experience with rufinamide as adjunctive drug in children, adolescents and young adults with refractory childhood-onset epileptic encephalopathies other than Lennox-Gastaut syndrome.Methods: Thirty-eight patients (19 males, 19 females), aged between 4 and 34 (mean 13.7± 8.3, median 12.5), all affected by different types of childhood-onset refractory epileptic encephalopathies other than Lennox-Gastaut syndrome, were treated with rufinamide as adjunctive drug for a mean period of 11.4 months (range 3-26 months).Results: Fifteen of 38 patients (39.5%) had a >50% seizure reduction in countable seizures. Complete seizure freedom was achieved in one of these patients (2.6%). Three patients (7.9%) had a 25-49% seizure reduction, whilst seizure frequency remained unchanged in 15 (39.5%) and increased in five patients (13.1%). Eleven patients (28.9%) reported adverse side effects. Vomiting was reported in five patients (13.1%); drowsiness, decreased appetite and irritability with migraine manifested in other four patients. They were transient and mild in all cases.Conclusion: Rufinamide may be an effective and well-tolerated adjunctive drug for the treatment of refractory childhood-onset epileptic encephalopathies other than Lennox-Gastaut syndrome. Rufinamide was most effective in patients with drop-attacks and (bi)frontal spike-wave discharges.

Original languageEnglish
Pages (from-to)246-251
Number of pages6
JournalEuropean Journal of Neurology
Volume18
Issue number2
DOIs
Publication statusPublished - Feb 2011

Keywords

  • Epileptic encephalopathies-childhood
  • Refractory seizures
  • Rufinamide

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Fingerprint Dive into the research topics of 'Rufinamide in refractory childhood epileptic encephalopathies other than Lennox-Gastaut syndrome'. Together they form a unique fingerprint.

Cite this