Running out of bullets: The challenging management of acute hepatitis and SARS-COV-2 from the SMatteo COvid19 Registry (SMACORE)

Marta Colaneri, Pietro Valsecchi, Luciano Perotti, Serena Ludovisi, Elena Seminari, Teresa Chiara Pieri, Paolo Sacchi, Raffaele Bruno

Research output: Contribution to journalArticlepeer-review

Abstract

Liver impairment is frequent in patients with novel coronavirus disease (COVID-19) and direct viral tropism for the liver has been proven. Since several of the currently administered drugs against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are possibly hepatotoxic, the management of patients with COVID-19 and liver failure is still an almost unexplored field. Taking this challenging case of acute HBV with persistent hyperbilirubinemia and SARS-COV-2 infection with respiratory distress as a starting point, we here loop through this condition. Where the available therapeutic options are scarce, we here propose hemoperfusion (HP) as an attractive alternative to both delay any late-stage progression of hyper inflammation process in COVID-19 and remove the toxins involved in acute liver failure.

Original languageEnglish
JournalLiver International
DOIs
Publication statusAccepted/In press - 2020

Keywords

  • COVID-19
  • HBV
  • hemoperfusion

ASJC Scopus subject areas

  • Hepatology

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