Rush desensitization in heparin hypersensitivity: A case report

G. Patriarca, M. Rossi, D. Schiavino, G. Schinco, G. Fais, C. Varano, R. Schiavello

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Among all the known drug intolerances, adverse reactions to heparin are not very common. No desensitization in patients with heparin hypersensitivity has ever been attempted. We report the case of a 55-year-old female patient with mitral stenosis and insufficiency, and tricuspid and aortic insufficiency. The patient underwent heparin treatment, and urticaria occurred with either s.c. calcium heparin or i.v. sodium heparin. Allergy testing (skin tests and patch tests) was negative. A pseudoallergic intolerance was diagnosed. Mitral valve replacement with the extracorporeal circulation method was necessary; therefore, heparin treatment was administered. A heparin rush desensitization together with antihistamine drugs (4 mg clorpheniramine maleate for 3 d) was started: 50 UI (0.5 mg) s.c. sodium heparin were first administered; within 4 d, 5000 UI (50 mg) sodium heparin was administered i.v. with no side-effects. A full-dosage heparin treatment was then administered and heart surgery was easily performed. During the postsurgical course, i.v. sodium heparin was smoothly replaced with s.c. calcium heparin (25 000 UI s.c. per day) and with oral anticoagulants (sodium warfarin).

Original languageEnglish
Pages (from-to)292-294
Number of pages3
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume49
Issue number4
Publication statusPublished - 1994

Fingerprint

Heparin
Hypersensitivity
Patch Tests
Extracorporeal Circulation
Mitral Valve Stenosis
Histamine Antagonists
Urticaria
Mitral Valve Insufficiency
Warfarin
Skin Tests
Drug-Related Side Effects and Adverse Reactions
Mitral Valve
Anticoagulants
Thoracic Surgery
Therapeutics
Pharmaceutical Preparations

Keywords

  • desensitization
  • heparin
  • hypersensitivity
  • urticaria

ASJC Scopus subject areas

  • Immunology

Cite this

Patriarca, G., Rossi, M., Schiavino, D., Schinco, G., Fais, G., Varano, C., & Schiavello, R. (1994). Rush desensitization in heparin hypersensitivity: A case report. Allergy: European Journal of Allergy and Clinical Immunology, 49(4), 292-294.

Rush desensitization in heparin hypersensitivity : A case report. / Patriarca, G.; Rossi, M.; Schiavino, D.; Schinco, G.; Fais, G.; Varano, C.; Schiavello, R.

In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 49, No. 4, 1994, p. 292-294.

Research output: Contribution to journalArticle

Patriarca, G, Rossi, M, Schiavino, D, Schinco, G, Fais, G, Varano, C & Schiavello, R 1994, 'Rush desensitization in heparin hypersensitivity: A case report', Allergy: European Journal of Allergy and Clinical Immunology, vol. 49, no. 4, pp. 292-294.
Patriarca, G. ; Rossi, M. ; Schiavino, D. ; Schinco, G. ; Fais, G. ; Varano, C. ; Schiavello, R. / Rush desensitization in heparin hypersensitivity : A case report. In: Allergy: European Journal of Allergy and Clinical Immunology. 1994 ; Vol. 49, No. 4. pp. 292-294.
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