S-100 protein and laminin: Immunocytochemical markers for human Schwann cells in vitro

Elio Scarpini, Gianni Meola, Pierluigi Baron, Sandro Beretta, Mariaelena Velicogna, Guglielmo Scarlato

Research output: Contribution to journalArticlepeer-review

Abstract

Human fetal and adult Schwann cells, which had been maintained in culture for 5 weeks according to an explant-reexplantation technique, were labeled by immuno-peroxidase using antibodies directed against S-100 protein and laminin in order to find specific antigenic markers. Immunocytochemical analysis of the distribution of both proteins showed that they were expressed in long-term cultures. The localization of S-100 protein and laminin in long-term cultures indicated that the expression of these proteins by human Schwann cells was not axon-dependent and also occurred in absence of myelin synthesis.

Original languageEnglish
Pages (from-to)77-83
Number of pages7
JournalExperimental Neurology
Volume93
Issue number1
DOIs
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neurology

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