S-Adenosylmethionine (AdoMet) Supplementation for Treatment of Chemotherapy-induced Liver Injury

Daniele Santini, Bruno Vincenzi, Cristian Massacesi, Antonio Picardi, Umberto Vespasiani Gentilucci, Vincenzo Esposito, Giuseppina Liuzzi, Annalisa La Cesa, Laura Rocci, Fabiana Marcucci, Vincenzo Montesarchio, Angela M. Groeger, Maurizio Bonsignori, Giuseppe Tonini, Alfonso Baldi

Research output: Contribution to journalArticle

Abstract

Background: Liver toxicity can be observed during treatment with most chemotherapic agents, and represents one of the principal causes of dose reduction or chemotherapy delays. S-Adenosylmethionine (AdoMet) plays a critical role in the synthesis of polyamines and provides cysteine for the production of glutathione (GSH), the major endogenous hepatoprotective agent. Our study was aimed at assessing the protective effect of AdoMet supplementation in cancer chemotherapy-induced liver toxicity. Patients and Methods: Fifty cancer patients who developed, for the first time, anticancer chemotherapy-induced liver toxicity were studied. Enrolled patients received oral AdoMet supplementation. Results: AST, ALT and LDH levels recorded at the moment of the recognition of liver toxicity were significantly reduced after one week of AdoMet therapy (respectively p: 0.009, 0.0005 and 0.012). AST, ALT and LDH decrease was confirmed after two weeks of treatment. Furthermore, the effect on these enzyme levels persisted in the following chemotherapy courses, permitting our patients to perform the scheduled chemotherapy courses with a minimal number of dose reductions or administration delays. The efficacy of AdoMet supplementation was not influenced by the presence of liver metastases, and no appreciable side-effects were recognized. Conclusion: The results of our study clearly demonstrate a protective effect of AdoMet in cancer chemotherapy-induced liver toxicity. Further large phase III studies are required to assess the real clinical benefit associated with AdoMet supplementation.

Original languageEnglish
Pages (from-to)5173-5179
Number of pages7
JournalAnticancer Research
Volume23
Issue number6 D
Publication statusPublished - Nov 2003

Keywords

  • AdoMet
  • Chemotherapy-induced liver toxicity
  • Glutathione
  • Hepatoprotection

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Santini, D., Vincenzi, B., Massacesi, C., Picardi, A., Gentilucci, U. V., Esposito, V., Liuzzi, G., La Cesa, A., Rocci, L., Marcucci, F., Montesarchio, V., Groeger, A. M., Bonsignori, M., Tonini, G., & Baldi, A. (2003). S-Adenosylmethionine (AdoMet) Supplementation for Treatment of Chemotherapy-induced Liver Injury. Anticancer Research, 23(6 D), 5173-5179.