S-adenosylmethionine inhibits ubiquitin-proteasome system in vitro and on rat vascular smooth muscle cells

Fabrizio D'Anselmi, Alessandra Cucina, Giuseppe Cavallaro, Mariano Bizzarri, Rosaria Adele Cavallaro, Andrea Fuso, Antonino Cavallaro, Sigfrido Scarpa

Research output: Contribution to journalArticle

Abstract

S-adenosylmethionine is a metabolite regulating many biological processes; S-adenosylmethionine effect on ubiquitin-proteasome system (UPS) has not been studied yet. We investigated S-adenosylmethionine effects on UPS activity both in vitro, by inhibitor screening assay, and in rat vascular smooth muscle cells, by Western Blot of proteasomal targets. We found that S-adenosylmethionine inhibited UPS activity.

Original languageEnglish
Pages (from-to)58-62
Number of pages5
JournalProtein and Peptide Letters
Volume15
Issue number1
DOIs
Publication statusPublished - Jan 2008

    Fingerprint

Keywords

  • 20S proteasome
  • Atherosclerosis
  • S-adenosylmethionine
  • Sulfur-containing aminoacids cycle
  • Ubiquitin-proteasome system
  • Vascular smooth muscle cells

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

D'Anselmi, F., Cucina, A., Cavallaro, G., Bizzarri, M., Cavallaro, R. A., Fuso, A., Cavallaro, A., & Scarpa, S. (2008). S-adenosylmethionine inhibits ubiquitin-proteasome system in vitro and on rat vascular smooth muscle cells. Protein and Peptide Letters, 15(1), 58-62. https://doi.org/10.2174/092986608783330396