S-adenosylmethionine inhibits ubiquitin-proteasome system in vitro and on rat vascular smooth muscle cells

Fabrizio D'Anselmi, Alessandra Cucina, Giuseppe Cavallaro, Mariano Bizzarri, Rosaria Adele Cavallaro, Andrea Fuso, Antonino Cavallaro, Sigfrido Scarpa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

S-adenosylmethionine is a metabolite regulating many biological processes; S-adenosylmethionine effect on ubiquitin-proteasome system (UPS) has not been studied yet. We investigated S-adenosylmethionine effects on UPS activity both in vitro, by inhibitor screening assay, and in rat vascular smooth muscle cells, by Western Blot of proteasomal targets. We found that S-adenosylmethionine inhibited UPS activity.

Original languageEnglish
Pages (from-to)58-62
Number of pages5
JournalProtein and Peptide Letters
Volume15
Issue number1
DOIs
Publication statusPublished - Jan 2008

Fingerprint

S-Adenosylmethionine
Proteasome Endopeptidase Complex
Ubiquitin
Vascular Smooth Muscle
Smooth Muscle Myocytes
Muscle
Rats
Cells
Biological Phenomena
Metabolites
Assays
Screening
Western Blotting
In Vitro Techniques

Keywords

  • 20S proteasome
  • Atherosclerosis
  • S-adenosylmethionine
  • Sulfur-containing aminoacids cycle
  • Ubiquitin-proteasome system
  • Vascular smooth muscle cells

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

D'Anselmi, F., Cucina, A., Cavallaro, G., Bizzarri, M., Cavallaro, R. A., Fuso, A., ... Scarpa, S. (2008). S-adenosylmethionine inhibits ubiquitin-proteasome system in vitro and on rat vascular smooth muscle cells. Protein and Peptide Letters, 15(1), 58-62. https://doi.org/10.2174/092986608783330396

S-adenosylmethionine inhibits ubiquitin-proteasome system in vitro and on rat vascular smooth muscle cells. / D'Anselmi, Fabrizio; Cucina, Alessandra; Cavallaro, Giuseppe; Bizzarri, Mariano; Cavallaro, Rosaria Adele; Fuso, Andrea; Cavallaro, Antonino; Scarpa, Sigfrido.

In: Protein and Peptide Letters, Vol. 15, No. 1, 01.2008, p. 58-62.

Research output: Contribution to journalArticle

D'Anselmi, F, Cucina, A, Cavallaro, G, Bizzarri, M, Cavallaro, RA, Fuso, A, Cavallaro, A & Scarpa, S 2008, 'S-adenosylmethionine inhibits ubiquitin-proteasome system in vitro and on rat vascular smooth muscle cells', Protein and Peptide Letters, vol. 15, no. 1, pp. 58-62. https://doi.org/10.2174/092986608783330396
D'Anselmi, Fabrizio ; Cucina, Alessandra ; Cavallaro, Giuseppe ; Bizzarri, Mariano ; Cavallaro, Rosaria Adele ; Fuso, Andrea ; Cavallaro, Antonino ; Scarpa, Sigfrido. / S-adenosylmethionine inhibits ubiquitin-proteasome system in vitro and on rat vascular smooth muscle cells. In: Protein and Peptide Letters. 2008 ; Vol. 15, No. 1. pp. 58-62.
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