S-Adenosylmethionine prevents oxidative stress and modulates glutathione metabolism in TgCRND8 mice fed a B-Vitamin deficient diet

Rosaria A. Cavallaro, Andrea Fuso, Vincenzina Nicolia, Sigfrido Scarpa

Research output: Contribution to journalArticlepeer-review

Abstract

Oxidative stress, altered glutathione levels, and hyperhomocysteinemia play critical roles in Alzheimer's disease. We studied the relationships between hyperhomocysteinemia, glutathione, and oxidative stress in TgCRND8 mice maintained in conditions of folate, B12, and B6 deficiency and the effect of S-adenosylmethionine supplementation. We found that hyperhomocysteinemia was correlated with increased reduced/oxidized brain glutathione ratio, with decreased glutathione S-transferase activity and increased lipid peroxidation. S-adenosylmethionine potentiated superoxide dismutase and glutathione S-transferase activity and restored altered brain glutathione and erythrocytes lipid peroxidation. These results underline the importance of S-adenosylmethionine as neuroprotective compound, acting both on methylation and oxidation metabolism.

Original languageEnglish
Pages (from-to)997-1002
Number of pages6
JournalJournal of Alzheimer's Disease
Volume20
Issue number4
DOIs
Publication statusPublished - 2010

Keywords

  • Amyloid-β
  • glutathione
  • homocysteine
  • oxidative stress
  • S-adenosylmethionine

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology
  • Medicine(all)

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