S-phase cell fraction in the prognosis of Dukes' stage D colorectal carcinoma

A. Faranda, A. Costa, R. Silvestrini, V. Quagliuolo, L. Gennari

Research output: Contribution to journalArticlepeer-review

Abstract

The S-phase cell fraction was prospectively defined as the [3H]-thymidine labeling index ([3H]dT LI) and flow cytometric S-phase (FCM-S) on 52 Dukes' D colorectal cancers. FCM-S estimates obtained by using different modeling systems were superimposible but they were weakly related to [3H]dT LI detected on the same tumour. Moreover, FCM-S values were higher in aneuploid than in diploid tumours, whereas [3H]dT LI values were independent of DNA-ploidy status. [3H]dT LI and FCM-S were also related differently to some clinical and pathological features such as tumour site and histology. [3H]dT LI and FCM-S were indicative of prognosis in terms of 2-year freedom from progression and overall survival. However, product-limit survival analysis showed an unexpectedly better freedom from progression and overall survival for patients with high S-phase tumours than for those with low S-phase tumours as defined by both cell kinetic variables.

Original languageEnglish
Pages (from-to)561-569
Number of pages9
JournalCell Proliferation
Volume27
Issue number9
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Cell Biology

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