(S)-WAY 100135, a 5-HT1A receptor antagonist, prevents the impairment of spatial learning caused by intrahippocampal scopolamine

Mirjana Carli, Roberto Luschi, Rosario Samanin

Research output: Contribution to journalArticlepeer-review

Abstract

Scopolamine, 3.75 μg/μl infused bilaterally into the CA1 region of the dorsal hippocampus 10 min before each training session, impaired choice accuracy but had no effect on choice latency or errors of omission in rats trained in a two-platform spatial discrimination task. Administered subcutaneously at 3 and 10 mg/kg 30 min before each training session, N-tert-butyl-3-4-(2-methoxyphenyl)piperazin-1-yl-2-phenylpropanamide dihydrochloride ((S)-WAY 100135), a 5-HT1A receptor antagonist, prevented the impairment of choice accuracy induced by intrahippocampal scopolamine. No subcutaneous dose of (S)-WAY 100135 by itself modified the acquisition of spatial learning. Administered into the dorsal hippocampus 15 min before each training session, (S)-WAY 100135 at doses of 0.2, 1 and 5 μg/μl did not affect the acquisition of spatial learning but dose dependently prevented the impairment of choice accuracy caused by scopolamine, 3.75 μg/μl infused into the same area. These findings suggest that blockade of 5-HT1A receptors can compensate the loss of cholinergic excitatory input on pyramidal cells, probably by favouring the action of other excitatory transmitters.

Original languageEnglish
Pages (from-to)133-139
Number of pages7
JournalEuropean Journal of Pharmacology
Volume283
Issue number1-3
DOIs
Publication statusPublished - Sep 5 1995

Keywords

  • (Rat)
  • (S)-WAY 100135
  • 5-HT receptor
  • Acetylcholine
  • Alzheimer disease
  • Hippocampus
  • Scopolamine
  • Spatial learning

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

Fingerprint

Dive into the research topics of '(S)-WAY 100135, a 5-HT1A receptor antagonist, prevents the impairment of spatial learning caused by intrahippocampal scopolamine'. Together they form a unique fingerprint.

Cite this