S100 beta protein is increased in fetuses with neural tube defect

Emanuela Marinoni, Alessandro Frigiola, Diego Gazzolo, Papaleo Greco, Antonella Vimercati, Massimo Moscarini, Raul Abella, Romolo Di Iorio

Research output: Contribution to journalArticlepeer-review


We investigated the levels of S100 beta protein (S100B) in the serum of fetuses with neural tube defects (NTD), and their mother. Samples from 20 fetuses with NTD and 30 controls at the same gestational age, and their mothers, were studied. S100B protein levels were determined using Lia-mat Sangtec. kit. S100B concentrations were significantly higher in NTD fetuses (median 2.71 microg/L) than in control subjects (median 0.98 microg/L). Increased S100B levels were also found in mothers carrying fetuses with NTD compared to control and uncomplicated pregnancies. This study indicates that NTD is associated with increased serum concentration of S100B in fetuses and mothers. Moreover, it gives information on S100B levels in the fetal circulation in early-mid gestation.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalFrontiers in Bioscience - Elite
Volume2 E
Issue number1
Publication statusPublished - Jan 1 2010


  • Brain development
  • Fetus
  • Neuronal tube defects
  • Pregnancy
  • S100 protein

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)


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