S100B increases in cyanotic versus noncyanotic infants undergoing heart surgery and cardiopulmonary bypass (CPB)

Alessandro Varrica, Angela Satriano, Antonio D W Gavilanes, Luc J Zimmermann, Hans J S Vles, Francesca Pluchinotta, Luigi Anastasia, Alessandro Giamberti, Ekaterina Baryshnikova, Diego Gazzolo

Research output: Contribution to journalArticlepeer-review


AIMS: S100B has been proposed as a consolidated marker of brain damage in infants with congenital heart disease (CHD) undergoing cardiac surgery and cardiopulmonary bypass (CPB). The present study aimed to investigate whether S100B blood levels in the perioperative period differed in infants complicated or not by cyanotic CHD (CHDc) and correlated with oxygenation status (PaO2).

METHODS: We conducted a case-control study of 48 CHD infants without pre-existing neurological disorders undergoing surgical repair and CPB. 24 infants were CHDc and 24 were CHD controls. Blood samples for S100B assessment were collected at six monitoring time-points: before the surgical procedure (T0), after sternotomy but before CPB (T1), at the end of the cross-clamp CPB phase (T2), at the end of CPB (T3), at the end of the surgical procedure (T4), at 24 h postsurgery (T5).

RESULTS: In the CHDc group, S100B multiples of median (MoM) were significantly higher (p < .05, for all) from T0 to T5. PaO2 was significantly lower (p < .05, for all) in CHDc infants at T0-T1 and at T4 while no differences (p > .05, for all) were found at T2, T3, T5. Linear regression analysis showed a positive correlation between S100B MoM at T3 and PaO2 (R = 0.84; p < .001).

CONCLUSIONS: The present data showing higher hypoxia/hyperoxia-mediated S100B concentrations in CHDc infants suggest that CHDc are more prone to perioperative brain stress/damage and suggest the usefulness of further investigations to detect the "optimal" PaO2 target in order to avoid the side effects associated with reoxygenation during CPB.

Original languageEnglish
Pages (from-to)1117-1123
Number of pages7
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number7
Publication statusPublished - Apr 2019


  • Arteries
  • Cardiac Surgical Procedures/adverse effects
  • Cardiopulmonary Bypass/adverse effects
  • Case-Control Studies
  • Cyanosis/blood
  • Female
  • Heart Defects, Congenital/surgery
  • Humans
  • Hyperoxia/blood
  • Hypoxia/blood
  • Infant
  • Male
  • Oxygen/blood
  • Partial Pressure
  • S100 Calcium Binding Protein beta Subunit/blood


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