S100B protein and near infrared spectroscopy in preterm and term newborns

Lucia Gabriella Tina, Alessandro Frigiola, Raul Abella, Paolo Tagliabue, Luisa Ventura, Giuseppe Paterlini, Giovanni Li Volti, Serena Pinzauti, Pasquale Florio, Valentina Bellissima, Carlo Minetti, Diego Gazzolo

Research output: Contribution to journalArticlepeer-review


Cerebral monitoring constitutes an emerging issue in perinatal medicine. Near Infrared Spectroscopy (NIRS) monitors brain oxygenation status in sick infants although data in healthy infants are lacking. The present study investigates whether NIRS parameters change according to gestational age and correlate with S100B protein. We recruited 64 healthy newborns (weeks' gestation: 30-42 wks) in which we performed in the first 6-hours after birth routine clinical, radiological and laboratory variables, cerebral oxygen saturation (rSO2), fractional cerebral tissue oxygen extraction (FTOE) values and S100B urine assessment. rSO2 and FTOE correlated (R=-0.73; R=0.51; P less than 0.01, for both) with gestational age. Highest rSO2 and the lowest FTOE peaks (P less than 0.001) were found at 30-33 wks. From 34 wks onwards, rSO2 progressively decreased and FTOE increased reaching their lower dip/peak (P less than 0.001) at 38-39 weeks. A significant correlation between S100B and NIRS parameters (rSO2: r=0.77; FTOE: r=-0.69; P less than 0.01) has been found. The present study shows that NIRS parameters and S100B protein correlation may be of help in brain function monitoring.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalFrontiers in Bioscience - Elite
Volume2 E
Issue number1
Publication statusPublished - Jan 1 2010


  • Brain damage
  • Brain oxygenation
  • Cerebrovascular system
  • NIRS
  • Prematurity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)


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