S100B urine concentrations in late preterm infants are gestational age and gender dependent

Andrea Sannia, Francesco Maria Risso, Luc J I Zimmermann, Antonio W D Gavilanes, Hans J. Vles, Diego Gazzolo

Research output: Contribution to journalArticle

Abstract

Background: Late preterm deliveries (LP, between 34 and 36. wks), have considerably increased in the last decades. About 20-25% of LP infants who require intensive care and morbidity on public health are of great magnitude. Therefore, we aimed at offering a reference curve in LP period of a well-established neurotrophic and brain damage marker namely S100B protein. Methods: We collected, between December 2009 and March 2012, urine samples, at first void (within 6-hours from birth) for S100B assessment, in 277 healthy LP infants consecutively admitted to our units. Standard clinical and laboratory monitoring parameters were also recorded. S100B was measured by using a commercially available immunoluminometric assay. Results: S100B pattern in LP infants was characterized by a slight decrease in protein's concentration from 34 to 35. wks. From 35. wks onwards S100B started to increase reaching a significant difference (P = 0.008) at 36. wks. When corrected for gender, significantly higher (P.

Original languageEnglish
Pages (from-to)31-34
Number of pages4
JournalClinica Chimica Acta
Volume417
DOIs
Publication statusPublished - Feb 8 2013

Fingerprint

Premature Infants
Gestational Age
Urine
Public health
Assays
Brain
Proteins
Critical Care
Monitoring
Public Health
Parturition
Morbidity

Keywords

  • Biomarkers
  • Brain development
  • Late-preterm
  • S100B

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Sannia, A., Risso, F. M., Zimmermann, L. J. I., Gavilanes, A. W. D., Vles, H. J., & Gazzolo, D. (2013). S100B urine concentrations in late preterm infants are gestational age and gender dependent. Clinica Chimica Acta, 417, 31-34. https://doi.org/10.1016/j.cca.2012.12.013

S100B urine concentrations in late preterm infants are gestational age and gender dependent. / Sannia, Andrea; Risso, Francesco Maria; Zimmermann, Luc J I; Gavilanes, Antonio W D; Vles, Hans J.; Gazzolo, Diego.

In: Clinica Chimica Acta, Vol. 417, 08.02.2013, p. 31-34.

Research output: Contribution to journalArticle

Sannia, A, Risso, FM, Zimmermann, LJI, Gavilanes, AWD, Vles, HJ & Gazzolo, D 2013, 'S100B urine concentrations in late preterm infants are gestational age and gender dependent', Clinica Chimica Acta, vol. 417, pp. 31-34. https://doi.org/10.1016/j.cca.2012.12.013
Sannia, Andrea ; Risso, Francesco Maria ; Zimmermann, Luc J I ; Gavilanes, Antonio W D ; Vles, Hans J. ; Gazzolo, Diego. / S100B urine concentrations in late preterm infants are gestational age and gender dependent. In: Clinica Chimica Acta. 2013 ; Vol. 417. pp. 31-34.
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