S100B urine concentrations in late preterm infants are gestational age and gender dependent

Andrea Sannia, Francesco Maria Risso, Luc J I Zimmermann, Antonio W D Gavilanes, Hans J. Vles, Diego Gazzolo

Research output: Contribution to journalArticlepeer-review


Background: Late preterm deliveries (LP, between 34 and 36. wks), have considerably increased in the last decades. About 20-25% of LP infants who require intensive care and morbidity on public health are of great magnitude. Therefore, we aimed at offering a reference curve in LP period of a well-established neurotrophic and brain damage marker namely S100B protein. Methods: We collected, between December 2009 and March 2012, urine samples, at first void (within 6-hours from birth) for S100B assessment, in 277 healthy LP infants consecutively admitted to our units. Standard clinical and laboratory monitoring parameters were also recorded. S100B was measured by using a commercially available immunoluminometric assay. Results: S100B pattern in LP infants was characterized by a slight decrease in protein's concentration from 34 to 35. wks. From 35. wks onwards S100B started to increase reaching a significant difference (P = 0.008) at 36. wks. When corrected for gender, significantly higher (P.

Original languageEnglish
Pages (from-to)31-34
Number of pages4
JournalClinica Chimica Acta
Publication statusPublished - Feb 8 2013


  • Biomarkers
  • Brain development
  • Late-preterm
  • S100B

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical


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