Saccadic parameters for early identification of neuronopathic Gaucher's disease

For a successfully treatment of the neurological form of Gaucher's Disease an early identification is necessary. Often an alteration of the horizontal saccadic eye movements constitutes the first sign of a central nervous system involvement In order to obtain an early identification of the neuronopathic forms of the disease, often masked by the use of the enzyme replacement therapy, the classical saccadic characteristics (Latency, Amplitude vs. Duration and Amplitude vs. Peak Velocity relationships) are not usable. This work studies if some other parameters (Mean Velocity/Peak Velocity, Kurtosis, Skewness, Asymmetry), able to describe the saccadic velocity profiles, could be considered to build an expert system able to reach the aim.