Saccadic parameters for early identification of neuronopathic Gaucher's disease

A. P. Accardo, S. Pensiero, P. Perissutti

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

For a successfully treatment of the neurological form of Gaucher's Disease an early identification is necessary. Often an alteration of the horizontal saccadic eye movements constitutes the first sign of a central nervous system involvement In order to obtain an early identification of the neuronopathic forms of the disease, often masked by the use of the enzyme replacement therapy, the classical saccadic characteristics (Latency, Amplitude vs. Duration and Amplitude vs. Peak Velocity relationships) are not usable. This work studies if some other parameters (Mean Velocity/Peak Velocity, Kurtosis, Skewness, Asymmetry), able to describe the saccadic velocity profiles, could be considered to build an expert system able to reach the aim.

Original languageEnglish
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Pages699-702
Number of pages4
Volume26 I
Publication statusPublished - 2004
EventConference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004 - San Francisco, CA, United States
Duration: Sep 1 2004Sep 5 2004

Other

OtherConference Proceedings - 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2004
CountryUnited States
CitySan Francisco, CA
Period9/1/049/5/04

Keywords

  • Eye movement
  • Gaucher's disease
  • Skwness

ASJC Scopus subject areas

  • Bioengineering

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