Saccharomyces boulardii for the prevention of antibiotic-associated diarrhea in adult hospitalized patients: A single-center, randomized, double-blind, placebo-controlled trial

Pietro Pozzoni, Alessia Riva, Alessandro Giacco Bellatorre, Maria Amigoni, Elena Redaelli, Anna Ronchetti, Mariangela Stefani, Rosangela Tironi, Edoardo Ennio Molteni, Dario Conte, Giovanni Casazza, Agostino Colli

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: Antibiotic-associated diarrhea (AAD) and Clostridium difficile-associated diarrhea (CDAD) are common complications of antibiotic use. Probiotics were effective in preventing AAD and CDAD in several randomized controlled trials. This study was aimed at testing the effect of Saccharomyces boulardii on the occurrence of AAD and CDAD in hospitalized patients. METHODS: A single-center, randomized, double-blind, placebo-controlled, parallel-group trial was performed. Patients being prescribed antibiotics or on antibiotic therapy for

Original languageEnglish
Pages (from-to)922-931
Number of pages10
JournalAmerican Journal of Gastroenterology
Volume107
Issue number6
DOIs
Publication statusPublished - Jun 2012

ASJC Scopus subject areas

  • Gastroenterology

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    Pozzoni, P., Riva, A., Bellatorre, A. G., Amigoni, M., Redaelli, E., Ronchetti, A., Stefani, M., Tironi, R., Molteni, E. E., Conte, D., Casazza, G., & Colli, A. (2012). Saccharomyces boulardii for the prevention of antibiotic-associated diarrhea in adult hospitalized patients: A single-center, randomized, double-blind, placebo-controlled trial. American Journal of Gastroenterology, 107(6), 922-931. https://doi.org/10.1038/ajg.2012.56