Abstract
Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by involuntary, jerky movements, incoordination, behavioral changes and subtle executive and cognitive impairment starting before motor symptoms. Our study aimed to assess the risky decision-making process in premanifest (pre) HD subjects, by means Game of Dice Task (GDT). As dependent variables, several GDT outcomes have been taken into consideration. We recruited 30 subjects (15 females) with preHD (i.e., Diagnosis Confidence Level < 4; Total Motor Score < 10), and 21 age, gender and education matched neurologically normal subjects (11 females). GDT is a computer-guided task where subjects are invited to watch the digits on which to bet and to evaluate the related potential risk to win or loss. Our results showed that decision and feedback times were longer in preHD than in neurologically normal group in both disadvantageous and advantageous choices. PreHD subjects provided a greater number of "safe" strategies, taken with longer decision-making time than neurologically normal subjects, showing a reduced propensity to risk. Such behavior, characterized by increased slowness in acting and providing answers, might contribute to delineate a behavioral and cognitive profile in preHD.
| Original language | English |
|---|---|
| Article number | 846 |
| Journal | Frontiers in Psychology |
| Volume | 10 |
| Issue number | MAR |
| DOIs | |
| Publication status | Published - Jan 1 2019 |
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Keywords
- Decision making
- Dorsolateral prefrontal cortex
- Executive functions
- Feedback processing
- Game of dice task
- Movement disorder
ASJC Scopus subject areas
- Psychology(all)
Cite this
Safer attitude to risky decision-making in premanifest Huntington's disease subjects. / D'Aurizio, Giulia; Migliore, Simone; Curcio, Giuseppe; Squitieri, Ferdinando.
In: Frontiers in Psychology, Vol. 10, No. MAR, 846, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Safer attitude to risky decision-making in premanifest Huntington's disease subjects
AU - D'Aurizio, Giulia
AU - Migliore, Simone
AU - Curcio, Giuseppe
AU - Squitieri, Ferdinando
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by involuntary, jerky movements, incoordination, behavioral changes and subtle executive and cognitive impairment starting before motor symptoms. Our study aimed to assess the risky decision-making process in premanifest (pre) HD subjects, by means Game of Dice Task (GDT). As dependent variables, several GDT outcomes have been taken into consideration. We recruited 30 subjects (15 females) with preHD (i.e., Diagnosis Confidence Level < 4; Total Motor Score < 10), and 21 age, gender and education matched neurologically normal subjects (11 females). GDT is a computer-guided task where subjects are invited to watch the digits on which to bet and to evaluate the related potential risk to win or loss. Our results showed that decision and feedback times were longer in preHD than in neurologically normal group in both disadvantageous and advantageous choices. PreHD subjects provided a greater number of "safe" strategies, taken with longer decision-making time than neurologically normal subjects, showing a reduced propensity to risk. Such behavior, characterized by increased slowness in acting and providing answers, might contribute to delineate a behavioral and cognitive profile in preHD.
AB - Huntington's disease (HD) is an inherited neurodegenerative disorder characterized by involuntary, jerky movements, incoordination, behavioral changes and subtle executive and cognitive impairment starting before motor symptoms. Our study aimed to assess the risky decision-making process in premanifest (pre) HD subjects, by means Game of Dice Task (GDT). As dependent variables, several GDT outcomes have been taken into consideration. We recruited 30 subjects (15 females) with preHD (i.e., Diagnosis Confidence Level < 4; Total Motor Score < 10), and 21 age, gender and education matched neurologically normal subjects (11 females). GDT is a computer-guided task where subjects are invited to watch the digits on which to bet and to evaluate the related potential risk to win or loss. Our results showed that decision and feedback times were longer in preHD than in neurologically normal group in both disadvantageous and advantageous choices. PreHD subjects provided a greater number of "safe" strategies, taken with longer decision-making time than neurologically normal subjects, showing a reduced propensity to risk. Such behavior, characterized by increased slowness in acting and providing answers, might contribute to delineate a behavioral and cognitive profile in preHD.
KW - Decision making
KW - Dorsolateral prefrontal cortex
KW - Executive functions
KW - Feedback processing
KW - Game of dice task
KW - Movement disorder
UR - http://www.scopus.com/inward/record.url?scp=85065185140&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065185140&partnerID=8YFLogxK
U2 - 10.3389/fpsyg.2019.00846
DO - 10.3389/fpsyg.2019.00846
M3 - Article
VL - 10
JO - Frontiers in Psychology
JF - Frontiers in Psychology
SN - 1664-1078
IS - MAR
M1 - 846
ER -