Safety and antitumor efficacy of 153Sm-EDTMP and docetaxel administered sequentially to patients with metastatic castration-resistant prostate cancer

Elisa Borsò, Giuseppe Boni, Ilaria Pastina, Alice Lorenzoni, Claudia Cianci, Francesca Federici, Sara Mazzarri, Cinzia Orlandini, Francesco Francesca, Cesare Selli, Sergio Ricci, Domenico Rubello, Giuliano Mariani

Research output: Contribution to journalArticle

Abstract

Background: Bone metastases are responsible for most of the morbidity associated with metastatic castration-resistant prostate cancer (mCRPC). Bone-seeking radiopharmaceuticals have been approved for palliation of painful skeletal metastases, but their clinical use is limited by concerns of toxicities both when administered alone and especially when combined with chemotherapy agents. Objective: We investigated whether docetaxel administered to mCRPC patients after treatment with samarium-153-labeled ethylene-diamine-tetra- methylene-phosphonic acid (153Sm-EDTMP) has increased toxicity and/or reduced antitumor efficacy. Materials and methods: Thirty mCRPC patients with skeletal metastases were enrolled. Patients received standard therapy with docetaxel (75 mg/m2 intravenously every 21 days for at least six cycles) on average 6 weeks after 153Sm-EDTMP (37 MBq/kg). Patients were monitored for the presence of toxicities, and antitumor efficacy was assessed by changes in serum prostate-specific antigen levels. Besides standard descriptive statistical analysis, progression-free survival and overall survival were defined using the Kaplan-Meier method. Results: Over 80% of the patients showed favorable biochemical responses. Median time to progression was 9.1 months (mean 9.8, 95% confidence interval 7.8-9.9), and median overall survival was 19.9 months (mean 24.5, 95% confidence interval 16.9-22.8); five patients were still alive over 5 years after enrollment. No additional hematological toxicities were observed when docetaxel was administered after 153Sm-EDTMP other than those expected when administering the agent alone. Conclusion: Prior administration of 153Sm-EDTMP does not cause additional toxicities for subsequent treatment with docetaxel and does not reduce the antitumor efficacy of the latter. This work justifies further investigations on the possible synergistic effects of combined strategies with the two agents.

Original languageEnglish
Pages (from-to)88-94
Number of pages7
JournalNuclear Medicine Communications
Volume35
Issue number1
DOIs
Publication statusPublished - Jan 2014

Keywords

  • Sm-EDTMP
  • Bone metastasis
  • Bone-seeking radiopharmaceuticals for therapy
  • Docetaxel
  • Metastatic castration-resistant prostate cancer
  • Sequential administration

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Borsò, E., Boni, G., Pastina, I., Lorenzoni, A., Cianci, C., Federici, F., Mazzarri, S., Orlandini, C., Francesca, F., Selli, C., Ricci, S., Rubello, D., & Mariani, G. (2014). Safety and antitumor efficacy of 153Sm-EDTMP and docetaxel administered sequentially to patients with metastatic castration-resistant prostate cancer. Nuclear Medicine Communications, 35(1), 88-94. https://doi.org/10.1097/MNM.0000000000000023