Safety and effectiveness of a transaortic approach for TAVI: procedural and midterm outcomes of 265 consecutive patients in a single centre

Mauro Romano, Andrea Daprati, Guglielmo Saitto, Francesco Tizzano, Daniel Le Houérou, Patrick Donzeau-Gouge, Arnaud Farge, Thierry Lefèvre, Thomas Hovasse, Andrea Garatti

Research output: Contribution to journalArticlepeer-review


OBJECTIVES: Transcatheter aortic valve implantation with a transaortic approach (TAo-TAVI) is an alternative to transapical or femoral access. We studied the procedural and midterm efficacy and safety of TAo-TAVI with Edwards Sapien XT and Medtronic CoreValve devices.

METHODS: Among 901 patients receiving TAVI since 2006, 265 consecutive patients underwent TAo-TAVI between January 2011 and September 2014. Procedural and midterm results were evaluated according to Valve Academic Research Consortium-2 criteria.

RESULTS: The mean age was 83 ± 5 years. Sapien XT and CoreValve were used in 191 (72.1%) and 74 (27.9%) patients, respectively. Full sternotomy made elective concomitant off-pump coronary artery bypass grafting possible in 38 patients (14.3%) with severe coronary artery disease unsuitable for percutaneous coronary intervention. The device success rate was 95.5%. Postprocedural paravalvular leak  ≥2/4 was observed in 16 patients (6.4%). Emergency open chest surgery was required in 10 patients (3.8%) (3 aortic dissections, 3 valve embolizations, 2 LMCA occlusions, 1 aortic annulus rupture and 1 aortic rupture). Cerebrovascular accidents occurred in 3 patients (1.1%). Transfusions  ≥4 units were required in 36 patients (13.6%). New pacemakers were implanted in 26 patients (9.8%). Thirty-day and 1-year mortality were 8.7% and 16.2%, respectively. Mean follow-up duration was 24 ± 6 months. At 3 years, freedom from all-cause death was 80% ± 4%. New York Heart Association class <III included 81% (n = 172) of patients alive and without prosthetic echocardiographic dysfunction at follow-up (mean gradient 10.5 ± 5.6 mmHg).

CONCLUSION: The TAo-TAVI approach confirms its safety and effectiveness with satisfactory procedural and midterm outcomes with both currently available devices.

Original languageEnglish
Pages (from-to)400-407
Number of pages8
JournalInteractive Cardiovascular and Thoracic Surgery
Issue number3
Publication statusPublished - Mar 1 2020


  • Aged
  • Aged, 80 and over
  • Aortic Valve Stenosis/complications
  • Cohort Studies
  • Coronary Artery Bypass, Off-Pump
  • Coronary Artery Disease/complications
  • Echocardiography
  • Female
  • Heart Valve Prosthesis
  • Humans
  • Male
  • Sternotomy
  • Transcatheter Aortic Valve Replacement/instrumentation
  • Treatment Outcome


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