The management of asymptomatic overanticoagulation with low dose vitamin K1 is recommended in patients taking oral anticoagulants, independently of the type of coumarin being administered. To evaluate the safety and effectiveness of this practice we observed 127 patients on warfarin and 14 on acenocoumarol, who received 2 mg oral vitamin K1 on at least one occasion. At the first measurement, international normalized ratio (INR) mean values were significantly lower in patients on acenocoumarol than in patients on warfarin (p=0.0001) and all patients on acenocoumarol showed INR values below the therapeutic range. Vitamin K1 should be used cautiously in patients being anticoagulated with acenocoumarol.
|Number of pages||2|
|Publication status||Published - Feb 1 2003|
- Oral anticoagulation
- Vitamin K1
ASJC Scopus subject areas