Safety and effectiveness of raltegravir in patients with haemophilia and anti-HIV multidrug resistance

L. Mangiafico, M. Perja, F. Fusco, S. Riva, D. Mago, A. Gringeri

Research output: Contribution to journalArticle

Abstract

Highly active antiretroviral therapy (HAART) of HIV+ patients with haemophilia poses specific questions on safety and effectiveness because of long-lasting HIV infection, multidrug resistance, concomitant chronic liver disease and bleeding risk. Raltegravir belongs to a new class of drugs that inhibits HIV integrase and is known to have a good effectiveness and safety profile. The aim of this study was to evaluate safety and effectiveness of HAART with raltegravir in patients with haemophilia. HIV+ patients with haemophilia treated with raltegravir for ≥6months were included in this retrospective study. Safety criteria were: occurrence of any adverse event, unexpected blood test abnormalities and increased consumption of coagulation factors. Effectiveness criteria were: no disease progression, viral load -1 and increased or stable CD3+ CD4+ cell count above 200cellscmm -1. Seven patients with HCV co-infection underwent treatment with raltegravir for a median of 20months (min-max: 7-30). Before starting treatment with raltegravir, three patients had CD3+ CD4+ cell counts -1. The median viral load was 7547copiesmL -1 (min-max: -1). CD3+ CD4+ cell counts showed a median increase of 152cellscmm -1 (min-max: 40-525). Two patients suffered from peripheral neuropathy, which was deemed as possibly associated with raltegravir. There was no evidence of increased bleeding frequency, modification of bleeding sites and lack of response to replacement therapy. Raltegravir-based HAART appeared to be effective and generally well-tolerated in patients with haemophilia, and it might represent a useful option in these patients.

Original languageEnglish
Pages (from-to)108-111
Number of pages4
JournalHaemophilia
Volume18
Issue number1
DOIs
Publication statusPublished - Jan 2012

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Keywords

  • Effectiveness
  • HAART
  • Haemophilia
  • HIV
  • Raltegravir
  • Safety

ASJC Scopus subject areas

  • Hematology
  • Genetics(clinical)

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