Safety and efficacy of first-generation and second-generation drug-eluting stents in the setting of acute coronary syndromes

Riccardo Gorla, Marco Loffi, Edoardo Verna, Alberto Margonato, Jorge Salerno-Uriarte

Research output: Contribution to journalArticlepeer-review

Abstract

Drug-eluting stents (DESs) are known to reduce in-stent restenosis rate, compared with bare metal stents (BMSs). Stent thrombosis, one of the most dangerous complications of DES, has emerged as a major concern. This issue has limited the use of DES in unstable coronary artery disease till recent years. In fact, acute coronary syndrome (ACS) and the subsequent activation of the hemocoagulative pathway could represent a prothrombotic environment, thus limiting the use of DES in this situation. Nowadays, there is increasing evidence in literature of similar stent thrombosis rates both for BMS and DES in ACS, and most interventional cardiologists are confident with the use of DES in ACS. The aim of this article is to review the current literature on this topic in order to compare first-generation and second-generation DES vs. BMS as concerns safety and efficacy.

Original languageEnglish
Pages (from-to)532-542
Number of pages11
JournalJournal of Cardiovascular Medicine
Volume15
Issue number7
DOIs
Publication statusPublished - 2014

Keywords

  • acute coronary syndromes
  • bare metal stent
  • drug-eluting stent
  • non-ST-elevation acute coronary syndrome
  • ST-elevation myocardial infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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