Safety and efficacy of gliadel wafers for newly diagnosed and recurrent glioblastoma

Pasquale De Bonis; Carmelo Anile; Angelo Pompucci; Alba Fiorentino; Mario Balducci; Silvia Chiesa; Giulio Maira; Annunziato Mangiola

doi:10.1007/s00701-012-1413-2

Safety and efficacy of gliadel wafers for newly diagnosed and recurrent glioblastoma

Pasquale De Bonis, Carmelo Anile, Angelo Pompucci, Alba Fiorentino, Mario Balducci, Silvia Chiesa, Giulio Maira, Annunziato Mangiola

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Background Combining Gliadel wafers and radiochemotherapy with TMZ may carry the risk of increased adverse events (AE). We analyzed the efficacy and safety in patients with glioblastoma who underwent multimodal treatment with implantation of Gliadel wafers. Methods One hundred sixty-five consecutive patients with newly diagnosed (77 patients) or recurrent (88 patients) glioblastoma were studied. Forty-seven patients underwent surgery + Gliadel. The impact of age (≥65 vs.

Original language	English
Pages (from-to)	1371-1378
Number of pages	8
Journal	Acta Neurochirurgica
Volume	154
Issue number	8
DOIs	https://doi.org/10.1007/s00701-012-1413-2
Publication status	Published - Aug 2012

Keywords

Carmustine-wafers
Efficacy
Gliadel
Glioblastoma
Safety
Toxicity

ASJC Scopus subject areas

Clinical Neurology
Surgery

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AU - De Bonis, Pasquale

AU - Anile, Carmelo

AU - Pompucci, Angelo

AU - Fiorentino, Alba

AU - Balducci, Mario

AU - Chiesa, Silvia

AU - Maira, Giulio

AU - Mangiola, Annunziato

PY - 2012/8

Y1 - 2012/8

N2 - Background Combining Gliadel wafers and radiochemotherapy with TMZ may carry the risk of increased adverse events (AE). We analyzed the efficacy and safety in patients with glioblastoma who underwent multimodal treatment with implantation of Gliadel wafers. Methods One hundred sixty-five consecutive patients with newly diagnosed (77 patients) or recurrent (88 patients) glioblastoma were studied. Forty-seven patients underwent surgery + Gliadel. The impact of age (≥65 vs.

AB - Background Combining Gliadel wafers and radiochemotherapy with TMZ may carry the risk of increased adverse events (AE). We analyzed the efficacy and safety in patients with glioblastoma who underwent multimodal treatment with implantation of Gliadel wafers. Methods One hundred sixty-five consecutive patients with newly diagnosed (77 patients) or recurrent (88 patients) glioblastoma were studied. Forty-seven patients underwent surgery + Gliadel. The impact of age (≥65 vs.

KW - Carmustine-wafers

KW - Efficacy

KW - Gliadel

KW - Glioblastoma

KW - Safety

KW - Toxicity

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Safety and efficacy of gliadel wafers for newly diagnosed and recurrent glioblastoma

Abstract

Keywords

ASJC Scopus subject areas

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