Safety and efficacy of high-dose acarbose treatment for dumping syndrome

Angela De Cunto, Egidio Barbi, Federico Minen, Alessandro Ventura

Research output: Contribution to journalArticlepeer-review

Abstract

Dumping syndrome (DS) is a complication of Nissen fundoplication. Dietary strategies can ameliorate symptoms, but this approach is not always foolproof. Limited evidence reports the efficacy of acarbose for children who are unresponsive to feeding manipulations. We report 8 patients with DS aged between 7 and 24 months. In 4 of 8 nutritional strategies failed, and acarbose treatment was started. The initial dose was 25 mg for meals, and increased until postprandial glucose was stable. In 3 of 4 children the final dose was higher than previously reported, without adverse effects. Acarbose is useful to treat DS in cases of failure of dietary strategies.

Original languageEnglish
Pages (from-to)113-114
Number of pages2
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume53
Issue number1
DOIs
Publication statusPublished - Jul 2011

Keywords

  • acarbose
  • dumping syndrome
  • hypoglycemia

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health

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