TY - JOUR
T1 - Safety and efficacy of l-lysine monohydrochloride and concentrated liquid l-lysine (base) produced by fermentation using Corynebacterium glutamicum strain KCCM 10227 for all animal species
AU - EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
AU - Bampidis, Vasileios
AU - Azimonti, Giovanna
AU - de Lourdes Bastos, Maria
AU - Christensen, Henrik
AU - Dusemund, Birgit
AU - Kouba, Maryline
AU - Kos Durjava, Mojca
AU - López-Alonso, Marta
AU - López Puente, Secundino
AU - Marcon, Francesca
AU - Mayo, Baltasar
AU - Pechová, Alena
AU - Petkova, Mariana
AU - Sanz, Yolanda
AU - Villa, Roberto Edoardo
AU - Woutersen, Ruud
AU - Costa, Lucio
AU - Cubadda, Francesco
AU - Dierick, Noël
AU - Flachowsky, Gerhard
AU - Mantovani, Alberto
AU - Wallace, Robert John
AU - Tarres-Call, Jordi
AU - Ramos, Fernando
N1 - © 2019 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.
PY - 2019/5
Y1 - 2019/5
N2 - Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l-lysine monohydrochloride and concentrated liquid l-lysine (base) produced using Corynebacterium glutamicum KCCM 10227 when used as nutritional additives in feed and water for drinking for all animal species. The active substance is l-lysine. l-lysine HCl and concentrated liquid l-lysine (base) produced by the strain C. glutamicum KCCM 10227 do not represent a risk for the target species, the consumer and the environment. l-lysine HCl produced by C. glutamicum KCCM 10227 is hazardous by inhalation, it is not irritant to skin but mildly irritant to eyes and it is not a skin sensitiser. Concentrated liquid l-lysine (base) produced by C. glutamicum KCCM 10227 is hazardous by inhalation, not irritant to skin and eyes and it is not a skin sensitiser. l-lysine HCl and concentrated liquid l-lysine (base) are considered as efficacious sources of the essential amino acid l-lysine for non-ruminant animal species. For the supplemental l-lysine to be as efficacious in ruminants as in non-ruminant species, it would require protection against degradation in the rumen.
AB - Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l-lysine monohydrochloride and concentrated liquid l-lysine (base) produced using Corynebacterium glutamicum KCCM 10227 when used as nutritional additives in feed and water for drinking for all animal species. The active substance is l-lysine. l-lysine HCl and concentrated liquid l-lysine (base) produced by the strain C. glutamicum KCCM 10227 do not represent a risk for the target species, the consumer and the environment. l-lysine HCl produced by C. glutamicum KCCM 10227 is hazardous by inhalation, it is not irritant to skin but mildly irritant to eyes and it is not a skin sensitiser. Concentrated liquid l-lysine (base) produced by C. glutamicum KCCM 10227 is hazardous by inhalation, not irritant to skin and eyes and it is not a skin sensitiser. l-lysine HCl and concentrated liquid l-lysine (base) are considered as efficacious sources of the essential amino acid l-lysine for non-ruminant animal species. For the supplemental l-lysine to be as efficacious in ruminants as in non-ruminant species, it would require protection against degradation in the rumen.
U2 - 10.2903/j.efsa.2019.5697
DO - 10.2903/j.efsa.2019.5697
M3 - Article
C2 - 32626320
VL - 17
SP - e05697
JO - EFSA Journal
JF - EFSA Journal
SN - 1831-4732
IS - 5
ER -