Safety and efficacy of the sulfydryl ACE-inhibitor zofenopril in the management of cardiovascular disease

Research output: Contribution to journalArticle

Abstract

In the 1970s, pharmacological therapy interrupting the renin-angiotensin system was considered beneficial for patients with high-renin hypertension. Angiotensin-converting enzyme (ACE) inhibitors proved to be effective not only in patients with high renin and elevated blood pressure, but also in many hypertensive patients with normal levels of plasma renin activity. ACE inhibitors are used in a wide range of chronic illnesses such as atherosclerosis, hypertension, myocardial infarction, heart failure, diabetic complications, and stroke. To date, more than ninety controlled clinical trials evaluating the beneficial effects of 14 different ACE inhibitors were conducted. Moreover, data from experimental studies showed that ACE inhibitors can attenuate the development of atherosclerosis, oxidative stress, and vascular inflammation in a wide range of species indicating that ACE inhibition also favourably affects the vasculature. More than fifteen years ago, the bi-sulfydryl ACE-inhibitor zofenopril has shown an excellent clinical safety and efficacy in patients with hypertension and in those with myocardial infarction. More recently, this compound exhibited a potent antioxidant and antiatherosclerotic effect indicating a clinical useful vasoprotective action.

Original languageEnglish
Pages (from-to)99-104
Number of pages6
JournalCardiovascular Therapy and Prevention (Russian Federation)
Volume10
Issue number6
Publication statusPublished - 2011

Keywords

  • ACE
  • Acute myocardial infarction
  • Atherosclerosis
  • Zofenopril

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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