Safety and prognostic role of regional lymphadenectomy for primary and metastatic liver tumors

Matteo Ravaioli, Giorgio Ercolani, Gian Luca Graz, Matteo Cescon, Alessandro Dazzi, Chiara Zanfi, Antonio Daniele Pinna

Research output: Contribution to journalArticlepeer-review

Abstract

Routine regional lymphadenectomy for colorectal liver metastases and primary liver tumors is still a subject for debate. During 2001-2005, we performed a prospective study of cases in which regional lymphadenectomy around the hepato-duodenal ligament and common hepatic artery was applied (group R? LN) or not (group R-LN). Pre-operative clinical features of patients were comparable among groups as well as the operative data. There were 108 (67%) males; the median age was 66 years; 124 cases had a single lesion (77%), and the median diameter was 4 cm. The type of lesion was: 77 (48%) colorectal liver metastases (M-CR), 75 (46%) hepatocellular carcinomas (HCC) and 10 (6%) cholangiocellular carcinomas. In the R? LN group, the mean number of lymph nodes removed was 6.7 ± 4.8 (range 4-26), and seven cases (8.6%) presented lymph node metastasis. The median follow-up was 3.5 years. M-CR patients showed comparable hospital mortality (R? LN 0% vs. R-LN 2.6%) and morbidity (R? LN 17.9% vs. R-LN 21.1%), but R? LN had higher 5-year disease-free survival (31 vs. 16%, p

Original languageEnglish
Pages (from-to)27-34
Number of pages8
JournalUpdates in Surgery
Volume62
Issue number1
DOIs
Publication statusPublished - 2010

Keywords

  • HCC
  • Hepatectomy
  • Liver metastases
  • Liver resection
  • Lymphadenectomy
  • Survival

ASJC Scopus subject areas

  • Surgery

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