Abstract
Objective. To analyze the safety of our biopsy technique and the effectiveness of minor salivary gland biopsy (MSGB) for the diagnosis of Sjögren's syndrome (SS) and amyloidosis. Methods. We conducted a retrospective analysis of 452 patients with suspected SS and 50 with suspected amyloidosis and negative periumbilical fat aspiration analysis who underwent MSGB at a single center. Diagnostic evaluation for SS included Schirmer's test, unstimulated whole salivary flow, detection of antinuclear antibodies and anti-SSA/SSB, erythrocyte sedimentation rate, C-reactive protein, IgM rheumatoid factor, and serology for hepatitis C virus. For all biopsy samples, a cumulative focus score on multilevel sections was calculated. SS was diagnosed according to American-European Consensus Group (AECG) criteria. Histologic evaluation for amyloidosis was performed using Congo red staining and polarized-light microscopy. Adverse events were recorded on a questionnaire immediately after the procedure and 7 days, 14 days, and 6 months thereafter. Results. Sixty-four patients (12.7%) reported transient adverse events: 40 paresthesias lasting
| Original language | English |
|---|---|
| Pages (from-to) | 714-720 |
| Number of pages | 7 |
| Journal | Arthritis Care and Research |
| Volume | 59 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 15 2008 |
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ASJC Scopus subject areas
- Rheumatology
Cite this
Safety and usefulness of minor salivary gland biopsy : Retrospective analysis of 502 procedures performed at a single center. / Caporali, Roberto; Bonacci, Eleonora; Epis, Oscar; Bobbio-Pallavicini, Francesca; Morbini, Patrizia; Montecucco, Carlomaurizio.
In: Arthritis Care and Research, Vol. 59, No. 5, 15.05.2008, p. 714-720.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Safety and usefulness of minor salivary gland biopsy
T2 - Retrospective analysis of 502 procedures performed at a single center
AU - Caporali, Roberto
AU - Bonacci, Eleonora
AU - Epis, Oscar
AU - Bobbio-Pallavicini, Francesca
AU - Morbini, Patrizia
AU - Montecucco, Carlomaurizio
PY - 2008/5/15
Y1 - 2008/5/15
N2 - Objective. To analyze the safety of our biopsy technique and the effectiveness of minor salivary gland biopsy (MSGB) for the diagnosis of Sjögren's syndrome (SS) and amyloidosis. Methods. We conducted a retrospective analysis of 452 patients with suspected SS and 50 with suspected amyloidosis and negative periumbilical fat aspiration analysis who underwent MSGB at a single center. Diagnostic evaluation for SS included Schirmer's test, unstimulated whole salivary flow, detection of antinuclear antibodies and anti-SSA/SSB, erythrocyte sedimentation rate, C-reactive protein, IgM rheumatoid factor, and serology for hepatitis C virus. For all biopsy samples, a cumulative focus score on multilevel sections was calculated. SS was diagnosed according to American-European Consensus Group (AECG) criteria. Histologic evaluation for amyloidosis was performed using Congo red staining and polarized-light microscopy. Adverse events were recorded on a questionnaire immediately after the procedure and 7 days, 14 days, and 6 months thereafter. Results. Sixty-four patients (12.7%) reported transient adverse events: 40 paresthesias lasting
AB - Objective. To analyze the safety of our biopsy technique and the effectiveness of minor salivary gland biopsy (MSGB) for the diagnosis of Sjögren's syndrome (SS) and amyloidosis. Methods. We conducted a retrospective analysis of 452 patients with suspected SS and 50 with suspected amyloidosis and negative periumbilical fat aspiration analysis who underwent MSGB at a single center. Diagnostic evaluation for SS included Schirmer's test, unstimulated whole salivary flow, detection of antinuclear antibodies and anti-SSA/SSB, erythrocyte sedimentation rate, C-reactive protein, IgM rheumatoid factor, and serology for hepatitis C virus. For all biopsy samples, a cumulative focus score on multilevel sections was calculated. SS was diagnosed according to American-European Consensus Group (AECG) criteria. Histologic evaluation for amyloidosis was performed using Congo red staining and polarized-light microscopy. Adverse events were recorded on a questionnaire immediately after the procedure and 7 days, 14 days, and 6 months thereafter. Results. Sixty-four patients (12.7%) reported transient adverse events: 40 paresthesias lasting
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UR - http://www.scopus.com/inward/citedby.url?scp=43549124592&partnerID=8YFLogxK
U2 - 10.1002/art.23579
DO - 10.1002/art.23579
M3 - Article
C2 - 18438907
AN - SCOPUS:43549124592
VL - 59
SP - 714
EP - 720
JO - Arthritis care and research : the official journal of the Arthritis Health Professions Association
JF - Arthritis care and research : the official journal of the Arthritis Health Professions Association
SN - 0893-7524
IS - 5
ER -