Safety of anti-TNFα agents in the treatment of psoriasis and psoriatic arthritis

Giampiero Girolomoni, Gianfranco Altomare, Fabio Ayala, Enzo Berardesca, Piergiacomo Calzavara-Pinton, Sergio Chimenti, Andrea Peserico, Antonio Puglisi Guerra, Gino Antonio Vena

Research output: Contribution to journalArticlepeer-review


Context: The efficacy and favorable safety profile of anti-tumor necrosis factor (TNF) agents in the treatment of psoriasis and psoriatic arthritis (PsA) are supported by several randomized controlled studies and meta-analyses. However, some concerns on the long-term safety of these drugs still exist, as these studies generally included small patient numbers and were performed in selected patient populations. Objective: This review presents and discusses current evidence on the safety of anti-TNFα agents in patients with psoriasis and PsA, with a focus on European registry studies and case reports of particular importance. Methods: Key studies on the safety of anti-TNFα agents in the treatment of adult patients with psoriasis or PsA were identified by a MEDLINE search (last updated 10 November 2011) based on several interrelated queries, with a focus on European registries. Other studies and case reports were included if deemed relevant. Studies concerning other conditions, such as rheumatoid arthritis (RA), were included as appropriate when data in psoriatic disease were unavailable or insufficient. Results: Available data on the safety of anti-TNFα agents such as etanercept in psoriasis and PsA appear reassuring, even if some concerns still exist. Most notably, data suggest a higher incidence of infection and lymphoma amongst patients treated with the anti-TNFα monoclonal antibodies infliximab and adalimumab compared with etanercept. Conclusion: The overall safety profile of monoclonal antibodies in patients with psoriasis, PsA and RA seems less favorable than that of etanercept, particularly in terms of risk of infection and hepatotoxicity.

Original languageEnglish
Pages (from-to)548-560
Number of pages13
JournalImmunopharmacology and Immunotoxicology
Issue number4
Publication statusPublished - Aug 2012


  • Adalimumab
  • Biological drugs
  • Etanercept
  • Golimumab
  • Infliximab
  • Psoriasis
  • Psoriatic arthritis
  • Registry
  • safety

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology
  • Toxicology


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