Safety of Food Oral Immunotherapy: What We Know, and What We Need to Learn: Immunology and Allergy Clinics of North America

S. Vázquez-Cortés, P. Jaqueti, S. Arasi, A. Machinena, M. Alvaro-Lozano, M. Fernández-Rivas

Research output: Contribution to journalArticlepeer-review

Abstract

Oral immunotherapy (OIT) for food allergy entails a risk of adverse reactions, including anaphylaxis. This safety concern is the major barrier for OIT to become a therapeutic option in clinical practice. The high heterogeneity in safety reporting of OIT studies prevents setting the safety profile accurately. An international consensus is needed to facilitate the analysis of large pooled clinical data with homogeneous safety reporting, that together with integrated omics, and patients/families’ opinions, may help stratify the patients’ risk and needs, and help developing safe(r) individualized care pathways. This will give OIT the right place in the food allergy therapy. © 2019 Elsevier Inc.
Original languageEnglish
Pages (from-to)111-133
Number of pages23
JournalImmunol. Allergy Clin. North Am.
Volume40
Issue number1
DOIs
Publication statusPublished - 2020

Keywords

  • Allergy
  • Food
  • Immunotherapy
  • Oral immunotherapy
  • Safety
  • antihistaminic agent
  • omalizumab
  • probiotic agent
  • allergen
  • anaphylaxis
  • disease marker
  • egg allergy
  • food allergy
  • gastrointestinal disease
  • health care need
  • human
  • immunotherapy
  • incidence
  • milk allergy
  • nonhuman
  • patient care
  • peanut allergy
  • phenotype
  • priority journal
  • Review
  • risk assessment
  • risk factor
  • safety
  • sesame
  • walnut
  • wheat allergy
  • adverse event
  • animal
  • desensitization
  • food
  • immunology
  • procedures
  • risk
  • Allergens
  • Anaphylaxis
  • Animals
  • Desensitization, Immunologic
  • Food Hypersensitivity
  • Humans
  • Risk

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