Safety of mud-bath applications in moderately active rheumatoid arthritis

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Objective: To evaluate safety of mud-bath therapy in mild-moderately rheumatoid arthritis RA. Methods: We planned a randomized, double-blinded, placebo-controlled trial in patients with moderate active RA, treated with active or placebo mud applied for 15 to 20 minutes at 39 to 40°C and followed by a shower and thermal bath at 37 to 38°C for 10 to 12 minutes. The first 50 patients were evaluated for an interim analysis and considered "treated patients" without blinding breakdown. Patients were evaluated before treatment visit 1, at the end of the treatment visit 2, after four weeks visit 3, and after six months visit 4, end of the study for flare, Disease Activity Score DAS, C-reactive protein, swollen joints, Health Assessment Questionnaire, and adverse reactions. As a control group, 50 matched RA patients were enrolled at the same outpatient clinic and evaluated four weeks apart. Results: The baseline characteristics of the two groups were similar. No significant differences were noted as for disease flares. Thirty-three 66 percent treated and 12 24 percent control patients had an improvement of more than 0.6 on the DAS p

Original languageEnglish
Pages (from-to)81-87
Number of pages7
JournalJournal of Musculoskeletal Pain
Issue number1
Publication statusPublished - 2010


  • Flares
  • Mud-bath therapy
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology


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