Safety of statins: Focus on clinical pharmacokinetics and drug interactions

Stefano Bellosta, Rodolfo Paoletti, Alberto Corsini

Research output: Contribution to journalArticlepeer-review

Abstract

Statin monotherapy is generally well tolerated, with a low frequency of adverse events. The most important adverse effects associated with statins are myopathy and an asymptomatic increase in hepatic transaminases, both of which occur infrequently. Because statins are prescribed on a long-term basis, however, possible interactions with other drugs deserve particular attention, as many patients will typically receive pharmacological therapy for concomitant conditions during the course of statin treatment. This review summarizes the pharmacokinetic properties of statins and emphasizes their clinically relevant drug interactions.

Original languageEnglish
JournalCirculation
Volume109
Issue number23 SUPPL.
Publication statusPublished - Jun 15 2004

Keywords

  • Drug interactions
  • Fibrates
  • Rhabdomyolysis
  • Safety
  • Statins

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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