Safety of transvenous lead extraction according to centre volume: a systematic review and meta-analysis

Antonio Di Monaco, Gemma Pelargonio, Maria L ucia Narducci, Lamberto Manzoli, Stefania Boccia, Maria E lena Flacco, Lorenzo Capasso, Lucy Barone, Francesco Perna, Gianluigi Bencardino, Teresa Rio, Milena Leo, Luigi Di Biase, Pasquale Santangeli, Andrea Natale, Antonio G iuseppe Rebuzzi, Filippo Crea

Research output: Contribution to journalArticlepeer-review


BACKGROUND: Transvenous lead extraction (TLE) is a complex invasive procedure and the experience of the operator and the team is a major determinant of procedural outcomes.

AIM: Because of very limited data available on minimum procedural volumes to enable training and ongoing competency for TLEs, we performed a meta-analysis aimed at assessing the outcomes of TLE in the centres with low, medium, and high volume of procedures.

METHODS: Of the 280 papers initially retrieved until February 2013, 66 observational studies met inclusion criteria and were included in at least one stratified meta-analysis: 17 were prospective studies; 47 had a retrospective design; and 2 were defined 'experience studies'. We included only articles published after the introduction of laser technique (year 1999). We divided the studies in low, medium, and high volume centres utilizing either the European Heart Rhythm Association (EHRA) or Lexicon classification criteria.

RESULTS: When meta-analyses were carried out separately for the studies with larger and smaller sample sizes, either using EHRA or Lexicon classification criteria, no clear differences emerged in the combined rate of major complications or intraoperative deaths. In contrast, both minor complications and mortality at 30 days decreased as centre volume increased.

CONCLUSIONS: In our meta-analysis of observational studies, patients who have been treated in higher volume centres have a lower probability of minor complications and death at 30 days regardless of the infection rate, length of lead duration, type of device, and type of extraction.

Original languageEnglish
Pages (from-to)1496-1507
Number of pages12
Issue number10
Publication statusPublished - Oct 1 2014


  • Cardiac device infection
  • Cardiac device malfunction
  • Cardiac endocarditis
  • Centre volume
  • Transvenous lead extraction

ASJC Scopus subject areas

  • Medicine(all)


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