Salicylate fails to prevent the inhibitory effect of 5,8,11,14-eicosatetraynoic acid on human platelet cyclo-oxygenase and lipoxygenase activities

Chiara Cerletti, Manuela Livio, Maria Gabriella Doni, Giovanni De Gaetano

Research output: Contribution to journalArticlepeer-review

Abstract

Sodium salicylate is inactive both on cyclo-oxygenase and lipoxygenase prepared from human platelets. It prevents the inhibition of cyclo-oxygenase induced by aspirin, but does not counteract the inhibitory effect of 5,8,11,14-eicosatetraynoic acid on both enzymes. It also fails to interfere with the inhibitory activity of nordihydroguaiaretic acid on lipoxygenase. These data indicate that, unlike eicosatetraynoic acid, non-steroidal anti-inflammatory drugs interact with a site on cyclo-oxygenase distinct from the catalytic site, although related to it. Such a supplementary binding site is lacking on lipoxygenase.

Original languageEnglish
Pages (from-to)125-127
Number of pages3
JournalBBA - General Subjects
Volume759
Issue number1-2
DOIs
Publication statusPublished - Aug 23 1983

Keywords

  • Cyclo-oxygenase
  • Eicosatetraynoic acid
  • Lipoxygenase
  • Salicylate

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Fingerprint Dive into the research topics of 'Salicylate fails to prevent the inhibitory effect of 5,8,11,14-eicosatetraynoic acid on human platelet cyclo-oxygenase and lipoxygenase activities'. Together they form a unique fingerprint.

Cite this