Salicylate fails to prevent the inhibitory effect of 5,8,11,14-eicosatetraynoic acid on human platelet cyclo-oxygenase and lipoxygenase activities

Chiara Cerletti, Manuela Livio, Maria Gabriella Doni, Giovanni De Gaetano

Research output: Contribution to journalArticle


Sodium salicylate is inactive both on cyclo-oxygenase and lipoxygenase prepared from human platelets. It prevents the inhibition of cyclo-oxygenase induced by aspirin, but does not counteract the inhibitory effect of 5,8,11,14-eicosatetraynoic acid on both enzymes. It also fails to interfere with the inhibitory activity of nordihydroguaiaretic acid on lipoxygenase. These data indicate that, unlike eicosatetraynoic acid, non-steroidal anti-inflammatory drugs interact with a site on cyclo-oxygenase distinct from the catalytic site, although related to it. Such a supplementary binding site is lacking on lipoxygenase.

Original languageEnglish
Pages (from-to)125-127
Number of pages3
JournalBBA - General Subjects
Issue number1-2
Publication statusPublished - Aug 23 1983



  • Cyclo-oxygenase
  • Eicosatetraynoic acid
  • Lipoxygenase
  • Salicylate

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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