Salicylic acid peel incorporating triethyl citrate and ethyl linoleate in the treatment of moderate acne: A new therapeutic approach

Beatrice Raone, Stefano Veraldi, Roberta Raboni, Marco Ardigò, Annalisa Patrizi, Giuseppe Micali

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Background Acne affects many adolescents. Conventional therapy often results in side effects and poor adherence, and the treatment does not consider the psychological effect of acne on patients, which is comparable with that of disabling diseases. Objectives To evaluate the efficacy and tolerability of a peel (30% salicylic acid, triethyl citrate and ethyl linoleate) combined with a home therapy with three topical agents (triethyl citrate, ethyl linoleate and salicylic acid 0.5% cream, lotion) in moderate acne of the face. Design Prospective, observational, multicenter, open-label, postmarketing, phase IV study. Methods Patients were assessed by comparing Global Acne Grading System (GAGS) score and total lesion count from 15 days before the first peel (T -15), after four salicylic peels (every 10 ± 2 days (T 0, T10, T20, T30), and 20 days after of the end of the study (T50). This treatment was associated to a home therapy. Results Fifty-three patients completed the study. The average GAGS score fell 49% between T-15 and T50 (p

Original languageEnglish
Pages (from-to)1243-1251
Number of pages9
JournalDermatologic Surgery
Issue number8
Publication statusPublished - Aug 2013


ASJC Scopus subject areas

  • Dermatology
  • Surgery

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