TY - JOUR
T1 - Saliva as a diagnostic matrix for drug abuse
AU - Lo Muzio, Lorenzo
AU - Falaschini, S.
AU - Rappelli, G.
AU - Bambini, F.
AU - Baldoni, A.
AU - Procaccini, M.
AU - Cingolani, M.
PY - 2005/7
Y1 - 2005/7
N2 - Scientific interest in saliva as a diagnostic matrix has greatly increased over the last decade. The Triage® screening test (Biosite Diagnostics), a rapid immunological test used to detect recreational drugs in the urine, was used to compare two biological matrixes: a non-conventional one, saliva, and a traditional one, urine. Twenty-one drug abusers collected one urine and one saliva specimen, both of which were tested with the Triage kit. Data were validated by gas-chromatography-mass-spectrometry (GC-MS). Results were positive for methadone in 9 saliva and 14 urine specimens, for opiates in 2 and 10, respectively, and for barbiturates in 2 specimens. Saliva specimens were negative for cannabis, THC, benzodiazepines and tricyclic antidepressants, although the GC-MS analysis revealed low concentrations of these drugs in the saliva. The study demonstrates the possibility of using saliva as a diagnostic matrix to test for drug-taking; however, the Triage kit must be improved before being used with saliva.
AB - Scientific interest in saliva as a diagnostic matrix has greatly increased over the last decade. The Triage® screening test (Biosite Diagnostics), a rapid immunological test used to detect recreational drugs in the urine, was used to compare two biological matrixes: a non-conventional one, saliva, and a traditional one, urine. Twenty-one drug abusers collected one urine and one saliva specimen, both of which were tested with the Triage kit. Data were validated by gas-chromatography-mass-spectrometry (GC-MS). Results were positive for methadone in 9 saliva and 14 urine specimens, for opiates in 2 and 10, respectively, and for barbiturates in 2 specimens. Saliva specimens were negative for cannabis, THC, benzodiazepines and tricyclic antidepressants, although the GC-MS analysis revealed low concentrations of these drugs in the saliva. The study demonstrates the possibility of using saliva as a diagnostic matrix to test for drug-taking; however, the Triage kit must be improved before being used with saliva.
KW - Drug abuse
KW - Immunological test
KW - Saliva
UR - http://www.scopus.com/inward/record.url?scp=27444437262&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=27444437262&partnerID=8YFLogxK
M3 - Article
C2 - 16164838
AN - SCOPUS:27444437262
VL - 18
SP - 567
EP - 573
JO - International Journal of Immunopathology and Pharmacology
JF - International Journal of Immunopathology and Pharmacology
SN - 0394-6320
IS - 3
ER -