Salivary duct carcinoma of the parotid gland: Report of a case with cytologic and immunocytochemical findings on fine needle aspiration biopsy

Maurizio Colecchia, Barbara Frigo, Orazio M. Leopardi

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: Salivary duct carcinoma (SDC) is a rare high grade neoplasm arising from the larger ducts of the major salivary glands, most frequently in the parotid glands in the elderly. It is important to identity some characteristics that allow differentiating SDC from the other salivary gland adenocarcinomas, which have different prognoses. CASE: A 63-year-old, white male presented with an indolent swelling in the left parotid gland, the retromandibular angle. Fine needle aspiration biopsy (FNAB) showed polygonal or cuboidal, medium-sized, moderately pleomorphic cells with round to oval nuclei in cytocentrifuge preparations. Small tissue fragments with a prominent cribriform pattern and an area of comedocarcinoma were observed in the cytocentrifuged material. Tumor cells were diffusely immunoreactive for low- and high-molecular-weight cytokeratins, and strong positivity was observed with 115D8 and Ber-EP4 antibodies. Overexpression of c-ERB B-2 was absent, and

Original languageEnglish
Pages (from-to)593-597
Number of pages5
JournalActa Cytologica
Volume41
Issue number2
Publication statusPublished - 1997

Keywords

  • aspiration biopsy
  • carcinoma
  • immunocytochemistry
  • parotid neoplasms

ASJC Scopus subject areas

  • Anatomy
  • Cell Biology
  • Histology

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