Salivary endothelin and vascular disorders in vibration-exposed workers

Massimo Bovenzi, Flavia D'Agostin, Francesca Rui, Luigi Ambrosi, Roberto Zefferino

Research output: Contribution to journalArticle

Abstract

Objectives: This study investigated the relation between salivary endothelin, vibration exposure, and vascular disorders in a group of forestry workers. Methods: Altogether 54 forestry workers and 52 controls underwent a medical examination and a cold test with measurement of the percentage of change in finger systolic blood pressure after finger cooling from 30°C to 10°C (FSBP%10°). Salivary endothelin concentration (ET1-21, in fmol/ml) was measured by a commercially available enzyme-linked immunosorbent assay before and after the cold challenge. The anamnestic diagnosis of vibration-induced white finger (VWF), assisted by color charts, was based on the Stockholm Workshop criteria. Results: Six forestry workers (11%) and one control (2%) reported white fingers. Before the cold challenge, the salivary ET1-21 concentration was significantly greater in the VWF workers than in the controls (P=0.036). The cold response of digital arteries was stronger in the VWF workers than in the controls (P1-21 concentration in both the controls and the forestry workers. For the latter, the salivary ET1-21 concentration was significantly associated with both daily and total operating time with vibrating tools. A significant inverse relation between FSBP%10°. and the salivary ET1-21 concentration was observed for the forestry workers with an abnormal cold response in their digital arteries. Conclusions: This study showed an association between salivary ET1-21 concentration, daily and cumulative vibration exposure, and vascular disorders in the fingers of professional forestry workers. Since ET1-21 can induce powerful and long-lasting constriction of human vessels, these findings suggest a possible role of this vasopeptide in the pathogenesis of VWF.

Original languageEnglish
Pages (from-to)133-141
Number of pages9
JournalScandinavian Journal of Work, Environment and Health
Volume34
Issue number2
Publication statusPublished - Apr 2008

Keywords

  • Cold challenge
  • Salivary endothelin
  • Vibration exposure
  • White finger

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Toxicology
  • Geography, Planning and Development
  • Health, Toxicology and Mutagenesis

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