Salivary nitrate, nitrite and N-nitroso compounds in patients with cancer of the upper aerodigestive tract

L. Airoldi, A. Galli, F. Mercato, F. Vago, R. Fanelli, E. Negri, C. La Vecchia, S. Vierucci

Research output: Contribution to journalArticlepeer-review

Abstract

N-nitroso compounds are carcinogens that can be ingested directly or synthesized from nitrites and nitrates. The possible role of N-nitroso compounds in the induction of upper aerodigestive tract turnouts was considered in a case-control study conducted in the Valle d'Aosta, an Italian region with a high incidence of these neoplasms. Nitrate, nitrite, labile and stable N-nitroso compounds were analysed in the saliva of 36 patients with cancers of the upper aerodigestive tract and 23 healthy individuals. After allowing for tobacco, salivary nitrate, nitrite and N-nitroso compounds were not associated with an increased risk of upper aerodigestive tract cancers. The odds ratio for continuous units of total N-nitroso compounds was 0.99 (95% confidence interval 0.9-1.1). Thus, salivary nitrate, nitrite and N- nitroso compounds might not be suitable markers for the assessment of the risk of cancer of the upper aerodigestive tract, although a role for N- nitroso compounds cannot be excluded.

Original languageEnglish
Pages (from-to)351-356
Number of pages6
JournalEuropean Journal of Cancer Prevention
Volume6
Issue number4
DOIs
Publication statusPublished - 1997

Keywords

  • N-nitroso compounds
  • Nitrate
  • Nitrite
  • Upper aerodigestive tract cancers

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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