Salt, endogenous ouabain and blood pressure interactions in the general population

Ji Guang Wang, Jan A. Staessen, Elisabetta Messaggio, Tim Nawrot, Robert Fagard, John M. Hamlyn, Giuseppe Bianchi, Paolo Manunta

Research output: Contribution to journalArticlepeer-review


Objective: Experimental data show that ouabain is a modulator of the sodium-potassium pump, which plays an important role in sodium homeostasis and blood pressure regulation. We investigated the distribution of plasma ouabain in the general population in relation to blood pressure and other determinants of sodium homeostasis. Methods: In 379 subjects enrolled in a Belgian population study, we measured plasma ouabain, clinical characteristics including blood pressure, serum and urinary electrolytes, urinary aldosterone excretion, various lifestyle factors, and the Gly460Trp polymorphism of the α-adducin gene. Our statistical methods included analysis of covariance and multiple linear regression. Results: Plasma ouabain (median, 140 pmol/l) correlated independently and positively with male gender (n = 182, P=0.002), smoking (n=116, P=0.05), urinary potassium excretion (mean 69 mmol/day, P

Original languageEnglish
Pages (from-to)1475-1481
Number of pages7
JournalJournal of Hypertension
Issue number8
Publication statusPublished - Aug 1 2003


  • Adducin
  • Blood pressure
  • Endogenous ouabain
  • Urinary sodium and potassium

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology


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