Salt, endogenous ouabain and blood pressure interactions in the general population

Ji Guang Wang, Jan A. Staessen, Elisabetta Messaggio, Tim Nawrot, Robert Fagard, John M. Hamlyn, Giuseppe Bianchi, Paolo Manunta

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Objective: Experimental data show that ouabain is a modulator of the sodium-potassium pump, which plays an important role in sodium homeostasis and blood pressure regulation. We investigated the distribution of plasma ouabain in the general population in relation to blood pressure and other determinants of sodium homeostasis. Methods: In 379 subjects enrolled in a Belgian population study, we measured plasma ouabain, clinical characteristics including blood pressure, serum and urinary electrolytes, urinary aldosterone excretion, various lifestyle factors, and the Gly460Trp polymorphism of the α-adducin gene. Our statistical methods included analysis of covariance and multiple linear regression. Results: Plasma ouabain (median, 140 pmol/l) correlated independently and positively with male gender (n = 182, P=0.002), smoking (n=116, P=0.05), urinary potassium excretion (mean 69 mmol/day, P

Original languageEnglish
Pages (from-to)1475-1481
Number of pages7
JournalJournal of Hypertension
Volume21
Issue number8
DOIs
Publication statusPublished - Aug 1 2003

Fingerprint

Ouabain
Salts
Blood Pressure
Population
Homeostasis
Sodium
Sodium-Potassium-Exchanging ATPase
Aldosterone
Electrolytes
Life Style
Linear Models
Potassium
Smoking
Serum
Genes

Keywords

  • Adducin
  • Blood pressure
  • Endogenous ouabain
  • Urinary sodium and potassium

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology

Cite this

Salt, endogenous ouabain and blood pressure interactions in the general population. / Wang, Ji Guang; Staessen, Jan A.; Messaggio, Elisabetta; Nawrot, Tim; Fagard, Robert; Hamlyn, John M.; Bianchi, Giuseppe; Manunta, Paolo.

In: Journal of Hypertension, Vol. 21, No. 8, 01.08.2003, p. 1475-1481.

Research output: Contribution to journalArticle

Wang, JG, Staessen, JA, Messaggio, E, Nawrot, T, Fagard, R, Hamlyn, JM, Bianchi, G & Manunta, P 2003, 'Salt, endogenous ouabain and blood pressure interactions in the general population', Journal of Hypertension, vol. 21, no. 8, pp. 1475-1481. https://doi.org/10.1097/00004872-200308000-00010
Wang JG, Staessen JA, Messaggio E, Nawrot T, Fagard R, Hamlyn JM et al. Salt, endogenous ouabain and blood pressure interactions in the general population. Journal of Hypertension. 2003 Aug 1;21(8):1475-1481. https://doi.org/10.1097/00004872-200308000-00010
Wang, Ji Guang ; Staessen, Jan A. ; Messaggio, Elisabetta ; Nawrot, Tim ; Fagard, Robert ; Hamlyn, John M. ; Bianchi, Giuseppe ; Manunta, Paolo. / Salt, endogenous ouabain and blood pressure interactions in the general population. In: Journal of Hypertension. 2003 ; Vol. 21, No. 8. pp. 1475-1481.
@article{9efa3c6e83e14aec9af84605ea29e684,
title = "Salt, endogenous ouabain and blood pressure interactions in the general population",
abstract = "Objective: Experimental data show that ouabain is a modulator of the sodium-potassium pump, which plays an important role in sodium homeostasis and blood pressure regulation. We investigated the distribution of plasma ouabain in the general population in relation to blood pressure and other determinants of sodium homeostasis. Methods: In 379 subjects enrolled in a Belgian population study, we measured plasma ouabain, clinical characteristics including blood pressure, serum and urinary electrolytes, urinary aldosterone excretion, various lifestyle factors, and the Gly460Trp polymorphism of the α-adducin gene. Our statistical methods included analysis of covariance and multiple linear regression. Results: Plasma ouabain (median, 140 pmol/l) correlated independently and positively with male gender (n = 182, P=0.002), smoking (n=116, P=0.05), urinary potassium excretion (mean 69 mmol/day, P",
keywords = "Adducin, Blood pressure, Endogenous ouabain, Urinary sodium and potassium",
author = "Wang, {Ji Guang} and Staessen, {Jan A.} and Elisabetta Messaggio and Tim Nawrot and Robert Fagard and Hamlyn, {John M.} and Giuseppe Bianchi and Paolo Manunta",
year = "2003",
month = "8",
day = "1",
doi = "10.1097/00004872-200308000-00010",
language = "English",
volume = "21",
pages = "1475--1481",
journal = "Journal of Hypertension",
issn = "0263-6352",
publisher = "Lippincott Williams and Wilkins",
number = "8",

}

TY - JOUR

T1 - Salt, endogenous ouabain and blood pressure interactions in the general population

AU - Wang, Ji Guang

AU - Staessen, Jan A.

AU - Messaggio, Elisabetta

AU - Nawrot, Tim

AU - Fagard, Robert

AU - Hamlyn, John M.

AU - Bianchi, Giuseppe

AU - Manunta, Paolo

PY - 2003/8/1

Y1 - 2003/8/1

N2 - Objective: Experimental data show that ouabain is a modulator of the sodium-potassium pump, which plays an important role in sodium homeostasis and blood pressure regulation. We investigated the distribution of plasma ouabain in the general population in relation to blood pressure and other determinants of sodium homeostasis. Methods: In 379 subjects enrolled in a Belgian population study, we measured plasma ouabain, clinical characteristics including blood pressure, serum and urinary electrolytes, urinary aldosterone excretion, various lifestyle factors, and the Gly460Trp polymorphism of the α-adducin gene. Our statistical methods included analysis of covariance and multiple linear regression. Results: Plasma ouabain (median, 140 pmol/l) correlated independently and positively with male gender (n = 182, P=0.002), smoking (n=116, P=0.05), urinary potassium excretion (mean 69 mmol/day, P

AB - Objective: Experimental data show that ouabain is a modulator of the sodium-potassium pump, which plays an important role in sodium homeostasis and blood pressure regulation. We investigated the distribution of plasma ouabain in the general population in relation to blood pressure and other determinants of sodium homeostasis. Methods: In 379 subjects enrolled in a Belgian population study, we measured plasma ouabain, clinical characteristics including blood pressure, serum and urinary electrolytes, urinary aldosterone excretion, various lifestyle factors, and the Gly460Trp polymorphism of the α-adducin gene. Our statistical methods included analysis of covariance and multiple linear regression. Results: Plasma ouabain (median, 140 pmol/l) correlated independently and positively with male gender (n = 182, P=0.002), smoking (n=116, P=0.05), urinary potassium excretion (mean 69 mmol/day, P

KW - Adducin

KW - Blood pressure

KW - Endogenous ouabain

KW - Urinary sodium and potassium

UR - http://www.scopus.com/inward/record.url?scp=0041736547&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0041736547&partnerID=8YFLogxK

U2 - 10.1097/00004872-200308000-00010

DO - 10.1097/00004872-200308000-00010

M3 - Article

C2 - 12872040

AN - SCOPUS:0041736547

VL - 21

SP - 1475

EP - 1481

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - 8

ER -