Salt-regulating hormones in young normotensive obese subjects effects of saline load

Giuseppe Licata, Massimo Volpe, Rosario Scaglione, Speranza Rubattu

Research output: Contribution to journalArticlepeer-review


To investigate whether the response of salt-regulating hormones to volume expansion is impaired in obese subjects, we assessed the effects of saline load (0.25 mlV kg · min · 120 min) in 9 young, healthy, normotensive obese subjects (body mass index, >30 kg/m2) and in 10 lean control subjects (body mass index, 2) matched for age, gender, height, and mean blood pressure. Hematocrit, plasma renin activity (PRA), plasma aldosterone (PA), atrial natriuretic factor (ANF), and urinary sodium excretion (UNa,V) were evaluated. Saline load increased ANF levels significantly (PPNaV increased more in lean than obese subjects during saline load. Comparisons of percent changes in ANF, PRA, and PA after saline load showed that the responses of lean and obese subjects were significantly different (PP

Original languageEnglish
Pages (from-to)I-20-I-24
Issue number1
Publication statusPublished - 1994


  • Atrial natriuretic factor
  • Hypertension
  • Obesity
  • Renin-angiotensin system
  • Sodium-dependent

ASJC Scopus subject areas

  • Internal Medicine


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